PMID- 1979827 OWN - NLM STAT- MEDLINE DCOM- 19910201 LR - 20190510 IS - 0146-4760 (Print) IS - 0146-4760 (Linking) VI - 14 IP - 5 DP - 1990 Sep-Oct TI - Detection of D,L-amphetamine, D,L-methamphetamine, and illicit amphetamine analogs using diagnostic products corporation's amphetamine and methamphetamine radioimmunoassay. PG - 321-4 AB - Cross-reactivity with Diagnostic Products Corporation (DPC) amphetamine and methamphetamine radioimmunoassay (RIA) reagents was determined for amphetamine, methamphetamine, and a number of amphetamine analogs. Concentrations from 100 to 100,000 ng/mL were assayed. 3,4-Methylenedioxyamphetamine (MDA) and 3,4-methylenedioxymethamphetamine (MDMA) showed significant cross-reactivity for the amphetamine and methamphetamine reagents respectively. 4-Hydroxymethamphetamine, 3,4-methylenedioxyethylamphetamine (MDEA), and N,N-dimethyl-MDA also showed significant cross-reactivity with the methamphetamine reagents, but less than MDMA. None of the other analogs showed a positive result with the amphetamine or methamphetamine reagents at even the highest concentration, although several did show measurable cross-reactivity. The L isomers of amphetamine and methamphetamine showed substantially less cross-reactivity than the D forms to which the respective antibody systems are targeted. FAU - Cody, J T AU - Cody JT AD - Air Force Drug Testing Laboratory, Brooks AFB, Texas 78235-5000. LA - eng PT - Journal Article PL - England TA - J Anal Toxicol JT - Journal of analytical toxicology JID - 7705085 RN - 0 (Amphetamines) RN - 0 (Indicators and Reagents) RN - 44RAL3456C (Methamphetamine) RN - 4764-17-4 (3,4-Methylenedioxyamphetamine) RN - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine) SB - IM MH - 3,4-Methylenedioxyamphetamine/analogs & derivatives/analysis/immunology MH - Amphetamines/*analysis MH - Cross Reactions MH - Indicators and Reagents MH - Isomerism MH - Methamphetamine/*analysis MH - N-Methyl-3,4-methylenedioxyamphetamine MH - Radioimmunoassay EDAT- 1990/09/01 00:00 MHDA- 1990/09/01 00:01 CRDT- 1990/09/01 00:00 PHST- 1990/09/01 00:00 [pubmed] PHST- 1990/09/01 00:01 [medline] PHST- 1990/09/01 00:00 [entrez] AID - 10.1093/jat/14.5.321 [doi] PST - ppublish SO - J Anal Toxicol. 1990 Sep-Oct;14(5):321-4. doi: 10.1093/jat/14.5.321.