PMID- 1979830
OWN - NLM
STAT- MEDLINE
DCOM- 19910207
LR  - 20190701
IS  - 0024-3205 (Print)
IS  - 0024-3205 (Linking)
VI  - 47
IP  - 26
DP  - 1990
TI  - Ketanserin pretreatment attenuates MDMA-induced dopamine release in the striatum 
      as measured by in vivo microdialysis.
PG  - 2401-8
AB  - Systemic administration of the amphetamine analogue, 
      3,4-methylenedioxymethamphetamine (MDMA) produced a dose-dependent increase in 
      the extracellular concentration of dopamine (DA) in the striatum as measured by 
      in vivo microdialysis in awake, freely-moving rats. The extracellular 
      concentration of the DA metabolite, 3,4-dihydroxyphenylacetic acid (DOPAC), was 
      significantly decreased in dialysate samples following the administration of MDMA 
      (10 and 20 mg/kg, i.p.). The serotonin-2 (5-HT2) antagonist ketanserin (3 mg/kg, 
      i.p.) had no effect on the extracellular concentration of DA or DOPAC in the 
      striatum of vehicle- treated rats. The administration of ketanserin (3 mg/kg) 1 
      hr prior to MDMA (20 mg/kg) significantly attenuated the MDMA- induced increase 
      in the extracellular concentration of DA without affecting the decrease in DOPAC 
      concentrations. These data are suggestive that MDMA administration increases DA 
      release in the striatum of awake, freely-moving rats. In addition, MDMA-induced 
      increase in the extracellular concentration of DA in the striatum is mediated, in 
      part, via 5-HT2 receptor mechanisms.
FAU - Nash, J F
AU  - Nash JF
AD  - Department of Psychiatry, School of Medicine, Case Western Reserve University, 
      Cleveland, Ohio 44106-5000.
LA  - eng
GR  - MH 41684/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Receptors, Serotonin)
RN  - 102-32-9 (3,4-Dihydroxyphenylacetic Acid)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - 97F9DE4CT4 (Ketanserin)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - 3,4-Dihydroxyphenylacetic Acid/analysis
MH  - 3,4-Methylenedioxyamphetamine/*analogs & derivatives/pharmacology
MH  - Animals
MH  - Corpus Striatum/drug effects/*metabolism
MH  - Dialysis
MH  - Dopamine/*metabolism
MH  - Ketanserin/*pharmacology
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, Serotonin/drug effects
EDAT- 1990/01/01 00:00
MHDA- 1990/01/01 00:01
CRDT- 1990/01/01 00:00
PHST- 1990/01/01 00:00 [pubmed]
PHST- 1990/01/01 00:01 [medline]
PHST- 1990/01/01 00:00 [entrez]
AID - 0024-3205(90)90484-9 [pii]
AID - 10.1016/0024-3205(90)90484-9 [doi]
PST - ppublish
SO  - Life Sci. 1990;47(26):2401-8. doi: 10.1016/0024-3205(90)90484-9.