PMID- 19799641
OWN - NLM
STAT- MEDLINE
DCOM- 20100212
LR  - 20211020
IS  - 1601-183X (Electronic)
IS  - 1601-1848 (Print)
IS  - 1601-183X (Linking)
VI  - 8
IP  - 7
DP  - 2009 Oct
TI  - Trpc2 gene impacts on maternal aggression, accessory olfactory bulb anatomy and 
      brain activity.
PG  - 639-49
LID - 10.1111/j.1601-183X.2009.00511.x [doi]
AB  - The Trpc2 gene codes for an ion channel found in the vomeronasal organ (VNO). 
      Studies using the Trpc2(-/-) (KO) mouse have exploited the gene's role in signal 
      transduction to explore the VNO's role in pheromonally mediated behaviors. To 
      date, no study has evaluated the impact of the Trpc2 gene on activity within the 
      brain. In this study, we examine the gene's effect on brain regions governing 
      maternal aggression. We intruder-tested lactating dams and then quantified Fos 
      immunoreactivity (Fos-IR) in the vomeronasal amygdala, hypothalamus, olfactory 
      regions and accessory olfactory bulb (AOB). Our data confirm previous reports 
      that loss of the Trpc2 gene severely diminishes maternal aggression. We also show 
      that deletion of the gene results in differential hypotrophy of the glomerular 
      layer (GlA) of the AOB, with the anterior portion the GlA resembling that of 
      wild-type mice, and the posterior portion reduced or absent. This anatomy is 
      suggestive of residual functioning in the apical VNO of these animals. Our Fos 
      study describes an impact of the deletion on a network of 21 brain regions 
      involved in emotion, aggression and olfaction, suggesting that signals from the 
      VNO mediate activity throughout the brain. Home-cage observations of KO dams show 
      specific deficits in nest-building, suggesting a role for pup pheromones in 
      inducing and maintaining pup-directed maternal behaviors as well as maternal 
      aggression.
FAU - Hasen, N S
AU  - Hasen NS
AD  - Center for Women's Health Research, University of Wisconsin-Madison, WI 53706, 
      USA. nshasen@wisc.edu
FAU - Gammie, S C
AU  - Gammie SC
LA  - eng
GR  - R01 MH066086/MH/NIMH NIH HHS/United States
GR  - R01 MH066086-04/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Genes Brain Behav
JT  - Genes, brain, and behavior
JID - 101129617
RN  - 0 (Pheromones)
RN  - 0 (TRPC Cation Channels)
RN  - 0 (Trpc2 protein, mouse)
SB  - IM
MH  - Aggression/*physiology
MH  - Amygdala/physiopathology
MH  - Animals
MH  - Animals, Newborn/physiology
MH  - Atrophy/genetics/metabolism/pathology
MH  - Female
MH  - Gene Expression Regulation/physiology
MH  - Hypothalamus/physiopathology
MH  - Limbic System/physiopathology
MH  - Male
MH  - Maternal Behavior/*physiology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Mice, Transgenic
MH  - Nerve Net/physiopathology
MH  - Olfactory Bulb/*metabolism/pathology/physiopathology
MH  - Olfactory Pathways/anatomy & histology/metabolism/physiopathology
MH  - Pheromones/*genetics
MH  - TRPC Cation Channels/*genetics
MH  - Vomeronasal Organ/*metabolism/physiopathology
PMC - PMC2758541
MID - NIHMS119948
EDAT- 2009/10/06 06:00
MHDA- 2010/02/13 06:00
PMCR- 2010/10/01
CRDT- 2009/10/06 06:00
PHST- 2009/10/06 06:00 [entrez]
PHST- 2009/10/06 06:00 [pubmed]
PHST- 2010/02/13 06:00 [medline]
PHST- 2010/10/01 00:00 [pmc-release]
AID - GBB511 [pii]
AID - 10.1111/j.1601-183X.2009.00511.x [doi]
PST - ppublish
SO  - Genes Brain Behav. 2009 Oct;8(7):639-49. doi: 10.1111/j.1601-183X.2009.00511.x.