PMID- 19800104
OWN - NLM
STAT- MEDLINE
DCOM- 20100212
LR  - 20220409
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 408
IP  - 1
DP  - 2009 Dec 15
TI  - Concentration of selected persistent organic pollutants in blood from delivering 
      women in South Africa.
PG  - 146-52
LID - 10.1016/j.scitotenv.2009.08.049 [doi]
AB  - Environmental exposure to persistent organic pollutants (POPs) may cause 
      detrimental health effects in the population with the developing foetus and 
      infants being at highest risk. This paper reports on the findings of the pilot 
      study that took place in seven geographical regions of South Africa, 96 pregnant 
      women admitted for delivery participated in the study. The following selected 
      POPs were analysed in maternal plasma: 15 polychlorinated biphenyls (PCBs) 
      congeners (IUPAC No. 28, 52, 99, 101, 105, 118, 138, 149, 153, 156, 170, 180, 
      183, 187, 194); six DDT metabolites (dichlordiphenyltrichloroethane p,p'-DDT and 
      o,p'-DDT; diphenyldichloroethylene p,p'-DDE and o,p'-DDE, dichlorophenylethane 
      p,p'-DDD o,p'-DDD) and other pesticides such as hexachlorocyclohexanes 
      (alpha-HCH, beta-HCH, gamma-HCH), hexachlorobenzene (HCB), heptachlor, chlordanes 
      (t-CD and c-CD), nanochlors (t-NC and c-NC) and mirex. The overall results showed 
      large regional differences with the rural site having the lowest levels for all 
      measured contaminants. The levels of PCB congeners were found to be low in all 
      samples and across all sites. DDT metabolites were detected in most participants 
      of this study and large regional differences were evident. Two malaria endemic 
      sites, where indoor residual spraying (IRS) with DDT takes place to control 
      malaria vector, were included in the study. The highest levels of DDTs were 
      measured in the coastal malaria site (Indian Ocean) with geometric means of 5177 
      ng/g lipid and 1797 ng/g lipid for p,p'-DDE and p,p'-DDT, and 1966 ng/g lipid and 
      726 ng/g lipid for p,p'-DDE and p,p'-DDT in inland malaria site. gamma-HCH was 
      found to be elevated overall, except for the urban community; the highest levels 
      were measured in the inland and coastal malaria sites. p,p'-DDT and gamma-HCH 
      were however not correlated, indicating different sources. The high DDT levels in 
      the malaria spraying regions as well as the elevated gamma-HCH levels are of 
      concern and call for extended monitoring of women and children in selected 
      regions.
FAU - Rollin, H B
AU  - Rollin HB
AD  - South African Medical Research Council, PO Box 87373, Houghton 2041, 
      Johannesburg, South Africa. hrollin@mrc.ac.za
FAU - Sandanger, T M
AU  - Sandanger TM
FAU - Hansen, L
AU  - Hansen L
FAU - Channa, K
AU  - Channa K
FAU - Odland, J O
AU  - Odland JO
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091001
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Environmental Pollutants)
RN  - 0 (Pesticides)
RN  - CIW5S16655 (DDT)
SB  - IM
MH  - Animals
MH  - Child
MH  - DDT/*blood/metabolism
MH  - Environmental Pollutants/adverse effects/*blood/metabolism
MH  - Female
MH  - Humans
MH  - Insect Vectors
MH  - Malaria/epidemiology
MH  - *Maternal Exposure/adverse effects
MH  - Pesticides/*blood/chemistry/metabolism
MH  - Pregnancy
MH  - Pregnancy Complications/*blood/chemically induced/metabolism
MH  - Risk Assessment
MH  - South Africa/epidemiology
EDAT- 2009/10/06 06:00
MHDA- 2010/02/13 06:00
CRDT- 2009/10/06 06:00
PHST- 2009/04/06 00:00 [received]
PHST- 2009/08/21 00:00 [revised]
PHST- 2009/08/25 00:00 [accepted]
PHST- 2009/10/06 06:00 [entrez]
PHST- 2009/10/06 06:00 [pubmed]
PHST- 2010/02/13 06:00 [medline]
AID - S0048-9697(09)00809-2 [pii]
AID - 10.1016/j.scitotenv.2009.08.049 [doi]
PST - ppublish
SO  - Sci Total Environ. 2009 Dec 15;408(1):146-52. doi: 
      10.1016/j.scitotenv.2009.08.049. Epub 2009 Oct 1.