PMID- 19800642
OWN - NLM
STAT- MEDLINE
DCOM- 20100315
LR  - 20221207
IS  - 1532-8600 (Electronic)
IS  - 0026-0495 (Linking)
VI  - 59
IP  - 3
DP  - 2010 Mar
TI  - Association of glycated albumin, but not glycated hemoglobin, with calcaneus 
      quantitative ultrasound in male hemodialysis patients with type 2 diabetes 
      mellitus.
PG  - 390-4
LID - 10.1016/j.metabol.2009.08.008 [doi]
AB  - Sustained high glucose impairs bone metabolism in patients with type 2 diabetes 
      mellitus (T2DM). In this study, the relationship between glycemic control and 
      bone metabolism was examined in male hemodialysis (HD) patients with T2DM. To 
      avoid the effect of menstruation and the menstrual cycle, obesity, and 
      glycosuria-induced hypercalciuria on bone metabolism, male anuric nonobese HD 
      patients with T2DM (n = 42) were enrolled. Calcaneus stiffness index (SI) was 
      determined using ultrasound after HD session. Casual plasma glucose (PG), 
      glycated hemoglobin (HbA(1c)), and glycated albumin (GA) were measured before the 
      HD session. In simple regression analysis, log PG (r = -0.333, P < .05) and log 
      GA (r = -0.350, P < .05), but not log HbA(1c) (r = -0.134, P = .3985), exhibited 
      significant and negative correlations with calcaneus SI. In multiple regression 
      analysis including log BMI, log cCa x Pi product, and log PG, log PG was 
      associated significantly in a negative manner with calcaneus SI, in addition to 
      log cCa x Pi product. When log PG was replaced with log GA or log HbA(1c), log 
      GA, but not log HbA(1c), emerged as a significant factor associated. The 
      mechanism as to why HbA(1c) failed to associate could be explained by its false 
      reduction by erythropoietin injection. The present study supported the notion of 
      GA as an appropriate indicator for glycemic control in HD patients with T2DM. 
      Furthermore, it is suggested that poor glycemic control might be a significant 
      factor toward decreasing calcaneus SI in T2DM HD patients.
CI  - (c) 2010 Elsevier Inc. All rights reserved.
FAU - Yamada, Shinsuke
AU  - Yamada S
AD  - Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City 
      University Graduate School of Medicine, Abeno-ku, Osaka 545-8585, Japan.
FAU - Inaba, Masaaki
AU  - Inaba M
FAU - Okada, Shigeki
AU  - Okada S
FAU - Imanishi, Yasuo
AU  - Imanishi Y
FAU - Mori, Katsuhito
AU  - Mori K
FAU - Emoto, Masanori
AU  - Emoto M
FAU - Ishimura, Eiji
AU  - Ishimura E
FAU - Nishizawa, Yoshiki
AU  - Nishizawa Y
LA  - eng
PT  - Journal Article
DEP - 20091002
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Glycoproteins)
RN  - 0 (Recombinant Proteins)
RN  - 0 (Serum Albumin)
RN  - 11096-26-7 (Erythropoietin)
SB  - IM
MH  - Aged
MH  - Blood Glucose/metabolism
MH  - Bone and Bones/metabolism
MH  - Calcaneus/*diagnostic imaging/metabolism
MH  - Diabetes Mellitus, Type 2/drug therapy/*metabolism
MH  - Diabetic Nephropathies/*metabolism
MH  - Erythropoietin/therapeutic use
MH  - Glycated Hemoglobin/*metabolism
MH  - Glycoproteins/metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Recombinant Proteins
MH  - Regression Analysis
MH  - *Renal Dialysis
MH  - Serum Albumin/*metabolism
MH  - Ultrasonography
EDAT- 2009/10/06 06:00
MHDA- 2010/03/17 06:00
CRDT- 2009/10/06 06:00
PHST- 2009/02/16 00:00 [received]
PHST- 2009/08/07 00:00 [revised]
PHST- 2009/08/09 00:00 [accepted]
PHST- 2009/10/06 06:00 [entrez]
PHST- 2009/10/06 06:00 [pubmed]
PHST- 2010/03/17 06:00 [medline]
AID - S0026-0495(09)00340-0 [pii]
AID - 10.1016/j.metabol.2009.08.008 [doi]
PST - ppublish
SO  - Metabolism. 2010 Mar;59(3):390-4. doi: 10.1016/j.metabol.2009.08.008. Epub 2009 
      Oct 2.