PMID- 19800964
OWN - NLM
STAT- MEDLINE
DCOM- 20100423
LR  - 20231105
IS  - 1090-2139 (Electronic)
IS  - 0889-1591 (Print)
IS  - 0889-1591 (Linking)
VI  - 24
IP  - 2
DP  - 2010 Feb
TI  - Association between depressive symptoms and fibrosis markers: the Cardiovascular 
      Health Study.
PG  - 229-35
LID - 10.1016/j.bbi.2009.09.017 [doi]
AB  - OBJECTIVE: Fibrosis plays an important role in heart failure (HF) and other 
      diseases that occur more frequently with increasing age. Depression is associated 
      with an increased risk of heart failure and other age-related diseases. This 
      study examined the association between depressive symptoms and fibrosis markers 
      in adults aged 65 years and above. METHODS: Fibrosis markers and depressive 
      symptoms were assessed in 870 participants (age=80.9+/-5.9 yrs, 49% women) using 
      a case-control design based on heart failure status (307 HF patients and 563 age- 
      and sex-matched controls, of whom 284 with CVD risk factors (hypertension, 
      diabetes mellitus, or hypercholesterolemia) and 279 controls without these CVD 
      risk factors). Fibrosis markers were procollagen type I (PIP), type I collagen 
      (CITP), and procollagen type III (PIIINP). Inflammation markers included 
      C-reactive protein, white blood cell counts and fibrinogen. Depression was 
      assessed using the Center for Epidemiological Studies-Depression (CES-D) scale 
      using a previously validated cut-off point for depression (CES-D > or = 8). 
      Covariates included demographic and clinical variables. RESULTS: Depression was 
      associated with higher levels of PIP (median=411.0, inter-quartile range 
      (IQR)=324.4-472.7 ng/mL vs. 387.6, IQR=342.0-512.5 ng/mL, p=0.006) and CITP 
      (4.99, IQR=3.53-6.85 vs. 4.53, IQR=3.26-6.22 microg/L, p=0.024), but not PIIIINP 
      (4.07, IQR=2.75-5.54 microg/L vs. 3.58, IQR=2.71-5.01 microg/L, p=0.29) compared 
      to individuals without depression. Inflammation markers were also elevated in 
      depressed participants (CRP, p=0.014; WBC, p=0.075; fibrinogen, p=0.074), but 
      these inflammation markers did not account for the relationship between 
      depression and fibrosis markers. CONCLUSIONS: Depression is associated with 
      elevated fibrosis markers and may therefore adversely affect heart failure and 
      other age-related diseases in which extra-cellular matrix formation plays a 
      pathophysiological role.
CI  - Copyright 2009 Elsevier Inc. All rights reserved.
FAU - Kop, Willem J
AU  - Kop WJ
AD  - Department of Medicine, University of Maryland, Baltimore, MD 21201, United 
      States. wkop@medicine.umaryland.edu
FAU - Kuhl, Emily A
AU  - Kuhl EA
FAU - Barasch, Eddy
AU  - Barasch E
FAU - Jenny, Nancy S
AU  - Jenny NS
FAU - Gottlieb, Stephen S
AU  - Gottlieb SS
FAU - Gottdiener, John S
AU  - Gottdiener JS
LA  - eng
GR  - R01 HL079376/HL/NHLBI NIH HHS/United States
GR  - U01 HL080295/HL/NHLBI NIH HHS/United States
GR  - R0-1 HL079376/HL/NHLBI NIH HHS/United States
GR  - R01 HL079376-04/HL/NHLBI NIH HHS/United States
GR  - N01HC55222/HL/NHLBI NIH HHS/United States
GR  - N01 HC-55222/HC/NHLBI NIH HHS/United States
GR  - N01-HC-75150/HC/NHLBI NIH HHS/United States
GR  - R01 HL066149-06/HL/NHLBI NIH HHS/United States
GR  - N01HC75150/HL/NHLBI NIH HHS/United States
GR  - N01-HC-85079/HC/NHLBI NIH HHS/United States
GR  - N01HC85079/HL/NHLBI NIH HHS/United States
GR  - N01-HC-85086/HC/NHLBI NIH HHS/United States
GR  - N01HC85086/HL/NHLBI NIH HHS/United States
GR  - 01-HC-45133/HC/NHLBI NIH HHS/United States
GR  - R01 HL066149/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20091002
PL  - Netherlands
TA  - Brain Behav Immun
JT  - Brain, behavior, and immunity
JID - 8800478
RN  - 0 (Biomarkers)
RN  - 0 (Collagen Type I)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Peptide Fragments)
RN  - 0 (Procollagen)
RN  - 0 (procollagen Type III-N-terminal peptide)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers
MH  - C-Reactive Protein/analysis/metabolism
MH  - Cardiovascular Diseases/epidemiology/*psychology
MH  - Collagen Type I/blood
MH  - Depression/epidemiology/*psychology
MH  - Electrocardiography
MH  - Endomyocardial Fibrosis/epidemiology/psychology
MH  - Fatigue/psychology
MH  - Female
MH  - Fibrosis/epidemiology/*psychology
MH  - Health Surveys
MH  - Heart Failure/epidemiology/psychology
MH  - Humans
MH  - Inflammation Mediators/blood
MH  - Male
MH  - Multivariate Analysis
MH  - Peptide Fragments/blood
MH  - Procollagen/blood
MH  - Psychiatric Status Rating Scales
MH  - Risk Factors
MH  - Socioeconomic Factors
PMC - PMC2818449
MID - NIHMS158256
EDAT- 2009/10/06 06:00
MHDA- 2010/04/24 06:00
PMCR- 2011/02/01
CRDT- 2009/10/06 06:00
PHST- 2009/08/03 00:00 [received]
PHST- 2009/09/18 00:00 [revised]
PHST- 2009/09/27 00:00 [accepted]
PHST- 2009/10/06 06:00 [entrez]
PHST- 2009/10/06 06:00 [pubmed]
PHST- 2010/04/24 06:00 [medline]
PHST- 2011/02/01 00:00 [pmc-release]
AID - S0889-1591(09)00440-1 [pii]
AID - 10.1016/j.bbi.2009.09.017 [doi]
PST - ppublish
SO  - Brain Behav Immun. 2010 Feb;24(2):229-35. doi: 10.1016/j.bbi.2009.09.017. Epub 
      2009 Oct 2.