PMID- 19804425
OWN - NLM
STAT- MEDLINE
DCOM- 20120209
LR  - 20171116
IS  - 1464-410X (Electronic)
IS  - 1464-4096 (Linking)
VI  - 105
IP  - 8
DP  - 2010 Apr
TI  - Type 2 diabetes but not metabolic syndrome is associated with an increased risk 
      of lower urinary tract symptoms and erectile dysfunction in men aged <45 years.
PG  - 1136-40
LID - 10.1111/j.1464-410X.2009.08913.x [doi]
AB  - OBJECTIVE: To investigate the association of type 2 diabetes mellitus (T2DM) and 
      metabolic syndrome with lower urinary tract symptoms (LUTS) and erectile 
      dysfunction (ED) in Taiwanese men aged <45 years. PATIENTS, SUBJECTS AND METHODS: 
      Voiding and erectile function in 226 men with T2DM, at one diabetes clinic, and 
      183 healthy men with normal fasting blood glucose levels, were compared. 
      Participants were evaluated using the International Prostate Symptom Score 
      (IPSS), the five-item version of the International Index of Erectile Function 
      questionnaire (IIEF-5), and measurements of flow rate and postvoid residual urine 
      volume. The association of metabolic syndrome with LUTS and ED was also 
      evaluated. RESULTS: The mean (sd, range) age of the patients was 38.9 (6.1, 
      20-45) years and the mean duration of diabetes was 2.8 (3.1, 0.5-20) years. 
      Compared with controls, men with T2DM had a significantly mean (sd) higher IPSS, 
      of 6.1 (5.8) vs 4.1 (4.6) (P < 0.001), an increased of odds ratio (95% confidence 
      interval) of having moderate to severe LUTS of 1.78 (1.12-2.84) (P = 0.01), 
      greater voiding volume of 376 (177) vs 326 (102) mL (P = 0.04), a worse IIEF-5 
      score of 17.3 (6.4) vs 20.0 (3.8) (P < 0.001), an increased of odds ratio of 
      having moderate to severe ED of 3.5 (2.1-5.8) (P < 0.001) but a similar maximum 
      flow rate and postvoid residual. The IIEF-5 score was negatively correlated with 
      the IPSS (P < 0.0001, coefficient = -0.23, 0.35-0.11) and glycosylated 
      haemoglobin (P = 0.02, coefficient = -0.14, 0.26-0.01). In all, 156 (69%) 
      patients met the criteria for metabolic syndrome. The mean age, duration of 
      diabetes, glycosylated haemoglobin, IPSS, voided volume, maximum urinary flow 
      rate and IIEF-5 score were similar between patients with and without metabolic 
      syndrome. CONCLUSIONS: Men with T2DM and aged <45 years had more LUTS but a 
      similar bladder emptying function than the controls. ED was highly prevalent and 
      was associated with the severity of LUTS. Metabolic syndrome did not aggravate 
      the severity of LUTS, emptying function or ED in the early stage of DM.
CI  - (c) 2009 THE AUTHORS. JOURNAL COMPILATION (c) 2009 BJU INTERNATIONAL.
FAU - Wang, Chung Cheng
AU  - Wang CC
AD  - Department of Biomedical Engineering, Chung Yuan Christian University, Chung-Li, 
      Taiwan.
FAU - Chancellor, Michael B
AU  - Chancellor MB
FAU - Lin, Jyh Ming
AU  - Lin JM
FAU - Hsieh, Jui Hsiang
AU  - Hsieh JH
FAU - Yu, Hong Jeng
AU  - Yu HJ
LA  - eng
PT  - Journal Article
DEP - 20091005
PL  - England
TA  - BJU Int
JT  - BJU international
JID - 100886721
SB  - IM
MH  - Adult
MH  - Body Mass Index
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*complications/physiopathology
MH  - Erectile Dysfunction/*etiology/physiopathology
MH  - Humans
MH  - Lower Urinary Tract Symptoms/*etiology/physiopathology
MH  - Male
MH  - Metabolic Syndrome/*complications/physiopathology
MH  - Middle Aged
MH  - Risk Factors
MH  - Urodynamics/physiology
MH  - Young Adult
EDAT- 2009/10/07 06:00
MHDA- 2012/02/10 06:00
CRDT- 2009/10/07 06:00
PHST- 2009/10/07 06:00 [entrez]
PHST- 2009/10/07 06:00 [pubmed]
PHST- 2012/02/10 06:00 [medline]
AID - BJU8913 [pii]
AID - 10.1111/j.1464-410X.2009.08913.x [doi]
PST - ppublish
SO  - BJU Int. 2010 Apr;105(8):1136-40. doi: 10.1111/j.1464-410X.2009.08913.x. Epub 
      2009 Oct 5.