PMID- 19806278
OWN - NLM
STAT- MEDLINE
DCOM- 20091228
LR  - 20190911
IS  - 0355-3140 (Print)
IS  - 0355-3140 (Linking)
VI  - 35
IP  - 6
DP  - 2009 Dec
TI  - Occupational asthma caused by inhalation of surfactant composed of amines.
PG  - 475-8
AB  - OBJECTIVE: Occupational asthma (OA) is highly prevalent in industrialized 
      countries and nearly 400 causal agents of this condition have been described to 
      date. This study aims to describe the case of a patient who developed OA 
      secondary to exposure to a surfactant agent comprised of alkylamine ethoxylate 
      and a mixture of alkyleneoxy and ethylenediamine. METHODS: We present the case of 
      a male worker in the meat industry suffering from OA resulting from exposure to a 
      surfactant agent used to clean the animal carcass before it is quartered. We 
      performed various tests on the individual, including: a chest computed 
      tomography; total serum immunoglobulin E (IgE) and specific IgE tests against 
      common pneumoallergens; pulmonary function studies; a methacholine test; and a 
      specific inhalation challenge to the surfactant agent. RESULTS: The tests 
      confirmed the diagnosis of OA. CONCLUSIONS: We discuss whether the amines present 
      in the surfactant or the agent itself might be the cause of the condition. 
      Because of the extensive use of surfactants in several types of industries, it is 
      reasonable to think that their possible relationship with OA may have relevant 
      health implications.
FAU - Villar-Gomez, Ana
AU  - Villar-Gomez A
AD  - Pneumology Department, Hospital Vall d'Hebron, Barcelona, Spain.
FAU - Munoz, Xavier
AU  - Munoz X
FAU - Culebras, Mario
AU  - Culebras M
FAU - Morell, Ferran
AU  - Morell F
FAU - Cruz, Maria-Jesus
AU  - Cruz MJ
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20091002
PL  - Finland
TA  - Scand J Work Environ Health
JT  - Scandinavian journal of work, environment & health
JID - 7511540
RN  - 0 (Alkanes)
RN  - 0 (Amines)
RN  - 0 (Detergents)
RN  - 0 (Ethylenediamines)
RN  - 60V9STC53F (ethylenediamine)
SB  - IM
MH  - *Abattoirs
MH  - Alkanes/adverse effects
MH  - Amines/*adverse effects
MH  - Asthma/*chemically induced
MH  - Detergents/*adverse effects
MH  - Ethylenediamines/adverse effects
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Occupational Diseases/*chemically induced
MH  - *Occupational Exposure
EDAT- 2009/10/07 06:00
MHDA- 2009/12/29 06:00
CRDT- 2009/10/07 06:00
PHST- 2009/10/07 06:00 [entrez]
PHST- 2009/10/07 06:00 [pubmed]
PHST- 2009/12/29 06:00 [medline]
AID - 1359 [pii]
AID - 10.5271/sjweh.1359 [doi]
PST - ppublish
SO  - Scand J Work Environ Health. 2009 Dec;35(6):475-8. doi: 10.5271/sjweh.1359. Epub 
      2009 Oct 2.