PMID- 19806574
OWN - NLM
STAT- MEDLINE
DCOM- 20100115
LR  - 20191210
IS  - 1003-9406 (Print)
IS  - 1003-9406 (Linking)
VI  - 26
IP  - 5
DP  - 2009 Oct
TI  - [Application of fluorescence in situ hybridization in prenatal diagnosis of 
      complex chromosomal abnormalities].
PG  - 529-32
LID - 10.3760/cma.j.issn.1003-9406.2009.05.011 [doi]
AB  - OBJECTIVE: To investigate the application of fluorescence in situ hybridization 
      (FISH) technique in prenatal diagnosis of complex chromosomal abnormalities. 
      METHODS: Eleven prenatal diagnosis cases (8 from amniocentesis and 3 from cord 
      blood) with complex chromosomal abnormalities detected by routine G-banding, were 
      further analyzed by FISH. RESULTS: The FISH technique confirmed the results of 
      balanced chromosome rearrangements detected by G-banding, and clarified the 
      structure of the derivative chromosomes in the 3 amniocentesis samples and the 
      origin of the mark chromosomes in the 2 cord blood samples. CONCLUSION: FISH can 
      be used to diagnose the complex chromosomal abnormalities accurately in prenatal 
      diagnosis, and can provide very useful genetic information for clinical diagnosis 
      and treatment.
FAU - Shen, Yan-yan
AU  - Shen YY
AD  - Xiamen Maternity and Child Health Care Hospital, Xiamen, Fujian, 361003, PR 
      China.
FAU - Li, Jian
AU  - Li J
FAU - Kong, Hui
AU  - Kong H
FAU - Wu, Hui-nan
AU  - Wu HN
FAU - Wu, Qiong
AU  - Wu Q
FAU - Ge, Yun-sheng
AU  - Ge YS
FAU - Huang, Xin-li
AU  - Huang XL
FAU - Zhou, Yu-lin
AU  - Zhou YL
LA  - chi
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi
JT  - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese 
      journal of medical genetics
JID - 9425197
SB  - IM
MH  - Amniotic Fluid/chemistry
MH  - *Chromosome Aberrations
MH  - Female
MH  - Fetal Blood/chemistry
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/*methods
MH  - Pregnancy/*genetics
MH  - Prenatal Diagnosis/*methods
EDAT- 2009/10/07 06:00
MHDA- 2010/01/16 06:00
CRDT- 2009/10/07 06:00
PHST- 2009/10/07 06:00 [entrez]
PHST- 2009/10/07 06:00 [pubmed]
PHST- 2010/01/16 06:00 [medline]
AID - 940626109 [pii]
AID - 10.3760/cma.j.issn.1003-9406.2009.05.011 [doi]
PST - ppublish
SO  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2009 Oct;26(5):529-32. doi: 
      10.3760/cma.j.issn.1003-9406.2009.05.011.