PMID- 1980848
OWN - NLM
STAT- MEDLINE
DCOM- 19910319
LR  - 20190613
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 529
IP  - 1-2
DP  - 1990 Oct 8
TI  - Methylenedioxymethamphetamine-induced hyperthermia and neurotoxicity are 
      independently mediated by 5-HT2 receptors.
PG  - 85-90
AB  - Methylenedioxymethamphetamine (MDMA) produced a significant hyperthermia in rats 
      which was antagonized in a competitive manner by the selective 5-HT2 antagonist, 
      MDL 11,939. The 5-HT antagonist also blocked MDMA-induced neurotoxicity as 
      assessed by the decline in regional 5-HT concentrations observed 1 week later. 
      These two effects of MDL 11,939 were dissociated at higher doses of MDMA where 
      the antagonist still provided virtually complete protection against the 
      neurochemical deficits but only partially attenuated the hyperthermic response. 
      In contrast to the effect of the 5-HT2 antagonist, haloperidol did not alter 
      MDMA-induced hyperthermia but did antagonize its long-term neurochemical effects. 
      Similarly, coadministration of the selective 5-HT uptake inhibitor, MDL 27,777, 
      did not affect the hyperthermia produced by a high dose of MDMA but completely 
      prevented the depletion of 5-HT. When the MDMA-induced hyperthermia was prevented 
      by temporarily maintaining animals at reduced ambient temperature, the 
      neurochemical changes normally observed 1 week later were also blocked. Although 
      these results demonstrate that the drugs tested do not antagonize MDMA-induced 
      neurotoxicity by interfering with its effect on body temperature, they do 
      indicate that MDMA-induced hyperthermia may contribute to the development of the 
      drug's long-term neurochemical effects.
FAU - Schmidt, C J
AU  - Schmidt CJ
AD  - Merrell Dow Research Institute, Cincinnati, OH 45215.
FAU - Black, C K
AU  - Black CK
FAU - Abbate, G M
AU  - Abbate GM
FAU - Taylor, V L
AU  - Taylor VL
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Neurotoxins)
RN  - 0 (Piperidines)
RN  - 0 (Receptors, Serotonin)
RN  - 0 (Serotonin Antagonists)
RN  - 107703-78-6 (alpha-phenyl-1-(2-phenylethyl)-4-piperidinemethanol)
RN  - 333DO1RDJY (Serotonin)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - J6292F8L3D (Haloperidol)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/*analogs & derivatives/pharmacology
MH  - Animals
MH  - Body Temperature/*drug effects
MH  - Cerebral Cortex/drug effects/*metabolism
MH  - Corpus Striatum/drug effects/*metabolism
MH  - Haloperidol/pharmacology
MH  - Hippocampus/drug effects/*metabolism
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Neurotoxins/*pharmacology
MH  - Piperidines/pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, Serotonin/drug effects/*physiology
MH  - Reference Values
MH  - Serotonin/*metabolism
MH  - Serotonin Antagonists/pharmacology
EDAT- 1990/10/08 00:00
MHDA- 1990/10/08 00:01
CRDT- 1990/10/08 00:00
PHST- 1990/10/08 00:00 [pubmed]
PHST- 1990/10/08 00:01 [medline]
PHST- 1990/10/08 00:00 [entrez]
AID - 0006-8993(90)90813-Q [pii]
AID - 10.1016/0006-8993(90)90813-q [doi]
PST - ppublish
SO  - Brain Res. 1990 Oct 8;529(1-2):85-90. doi: 10.1016/0006-8993(90)90813-q.