PMID- 19810295
OWN - NLM
STAT- MEDLINE
DCOM- 20091110
LR  - 20091008
IS  - 1022-386X (Print)
IS  - 1022-386X (Linking)
VI  - 15
IP  - 10
DP  - 2005 Oct
TI  - Comparison of unfractionated heparin vs low molecular weight heparin in the 
      treatment of acute deep vein thrombosis.
PG  - 601-4
AB  - OBJECTIVE: To compare the results of unfractionated heparin (UFH) with low 
      molecular weight heparin in the treatment of acute deep vein thrombosis of lower 
      limb. DESIGN: Randomized control trial. PLACE AND DURATION OF STUDY: Bolan 
      Medical Complex Hospital, Quetta from January 2002 to July 2003. PATIENTS AND 
      METHODS: Thirty patients who presented with acute deep vein thrombosis of lower 
      limb, confirmed by either Doppler ultrasonography or venography, were selected 
      for the study. Patients were divided randomly into two groups for treatment. 
      Group 1 was started with unfractionated heparin while group 2 with low molecular 
      weight heparin. Comparison of two treatments to determine the efficacy was done 
      by certain criteria like pain improvement, reduction in swelling, alteration in 
      bleeding profile, complications of therapy, recurrence, morbidity and mortality. 
      RESULTS: The age of the patients ranged from 16-82 years. There were 15 females 
      (50.00%) and 15 males (50.00%). Pain and swelling were present in all patients 
      (100%), while temperature and superficial vein dilation in 43.3% and 30% 
      respectively. The distribution of DVT in left lower limb was in 13 patients 
      (43.33%), right lower limb involvement in 12 patients (40.00%) and both limbs 
      involvement in 5 patients (16.67%). In group 1 improvement in pain occurred after 
      4th day in 13 patients, while in group 2 before 4th day in 8 patients (p-value = 
      0.068). Improvement in swelling was observed after 6th day in 11 patients (group 
      1), while before 6th day in 8 patients (group 2) (p-value = 0.171). Bleeding time 
      was prolonged in 5 patients in group 1 and statistically found significant 
      (p-value = 0.014), while in group 2 it was normal. Thromboembolism in 3 patients 
      and major bleeding was observed in 2 patients in group 1, while in group 2 it was 
      normal. Recurrence was reported in 2 patients in group 1 and 1 patient in group 2 
      (p-value 0.0815). The hospital stay was more than 10 days in group 1 (12 
      patients), and less than 10 days in group 2 (13 patients). It was found 
      statistically significant (p-value = 0.001). Three patients died in group 1, 
      while no mortality was observed in group 2. CONCLUSION: Treatment with low 
      molecular weight heparin (LMWH) has good patient compliance and is easy to 
      administer. LMWH has an advantage over UFH due to its normal bleeding profile and 
      significantly less hospital stay.
FAU - Naz, Rubina
AU  - Naz R
AD  - Department of Medicine, Bolan Medical Complex Hospital, Quetta. 
      rubina87300@yahoo.com
FAU - Naz, Samina
AU  - Naz S
FAU - Mehboob, Mukhtar
AU  - Mehboob M
FAU - Khalid, Ghulam Haider
AU  - Khalid GH
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Pakistan
TA  - J Coll Physicians Surg Pak
JT  - Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
JID - 9606447
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Heparin/*therapeutic use
MH  - Heparin, Low-Molecular-Weight/*therapeutic use
MH  - Humans
MH  - Length of Stay
MH  - Male
MH  - Middle Aged
MH  - Venous Thrombosis/*drug therapy
MH  - Young Adult
EDAT- 2005/10/01 00:00
MHDA- 2009/11/11 06:00
CRDT- 2009/10/09 06:00
PHST- 2009/10/09 06:00 [entrez]
PHST- 2005/10/01 00:00 [pubmed]
PHST- 2009/11/11 06:00 [medline]
PST - ppublish
SO  - J Coll Physicians Surg Pak. 2005 Oct;15(10):601-4.