PMID- 19811108
OWN - NLM
STAT- MEDLINE
DCOM- 20100511
LR  - 20220408
IS  - 1532-2513 (Electronic)
IS  - 0892-3973 (Linking)
VI  - 32
IP  - 1
DP  - 2010 Mar
TI  - Methanol extract of Phellodendri cortex alleviates lipopolysaccharide-induced 
      acute airway inflammation in mice.
PG  - 110-5
LID - 10.3109/08923970903193325 [doi]
AB  - BACKGROUND AND AIM: The effects of methanol extract of Phellodendri cortex on 
      acute airway inflammation induced by intranasal administration of 
      lipopolysaccharide (LPS, 300mug/kg) were investigated in female BALB/c mice. 
      MATERIALS AND METHODS: At 2 h after LPS exposure, mice were treated orally with 
      methanol extract of Phellodendri cortex (100, 200 and 400 mg/kg). At the end of 
      this study, bronchoalveolar lavage fluids (BALF) were collected and number of 
      total cells, macrophages and neutrophils, protein concentration were analyzed. 
      Tumor necrosis factor-alpha (TNF-alpha), macrophage inflammatory protein (MIP-2), 
      IL-10 levels and nitric oxide (NO) production in BALF were also determined. 
      RESULTS: Methanol extract of Phellodendri cortex dose-dependently alleviated 
      LPS-induced acute airway inflammation via decreasing the infiltration of 
      inflammatory cells and the release of inflammatory mediators. CONCLUSION: The 
      relief of airway inflammation provides a possible therapeutic application of 
      Phellodendri cortex for the treatment of infectious pulmonary diseases.
FAU - Mao, Yan-Fei
AU  - Mao YF
AD  - Departments of Surgical Intensive Care Unit, Xinhua Hospital,Shanghai Jiaotong 
      University School of Medicine, Shanghai, P. R. China.
FAU - Li, Yong-Qi
AU  - Li YQ
FAU - Zong, Lin
AU  - Zong L
FAU - You, Xin-Min
AU  - You XM
FAU - Lin, Fu-Qing
AU  - Lin FQ
FAU - Jiang, Lai
AU  - Jiang L
LA  - eng
PT  - Journal Article
PL  - England
TA  - Immunopharmacol Immunotoxicol
JT  - Immunopharmacology and immunotoxicology
JID - 8800150
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Plant Extracts)
SB  - IM
MH  - Acute Disease
MH  - Animals
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Lipopolysaccharides/toxicity
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - *Phellodendron
MH  - *Phytotherapy
MH  - Plant Extracts/*therapeutic use
MH  - Pneumonia/*drug therapy
EDAT- 2009/10/09 06:00
MHDA- 2010/05/12 06:00
CRDT- 2009/10/09 06:00
PHST- 2009/10/09 06:00 [entrez]
PHST- 2009/10/09 06:00 [pubmed]
PHST- 2010/05/12 06:00 [medline]
AID - 10.3109/08923970903193325 [doi]
PST - ppublish
SO  - Immunopharmacol Immunotoxicol. 2010 Mar;32(1):110-5. doi: 
      10.3109/08923970903193325.