PMID- 19811463
OWN - NLM
STAT- MEDLINE
DCOM- 20100517
LR  - 20091008
IS  - 1600-0897 (Electronic)
IS  - 1046-7408 (Linking)
VI  - 62
IP  - 5
DP  - 2009 Nov
TI  - Pre-eclampsia, placental abruption and increased risk of atopic sensitization in 
      male adolescent offspring.
PG  - 293-300
LID - 10.1111/j.1600-0897.2009.00738.x [doi]
AB  - PROBLEM: The aim of this study was to investigate maternal pre-eclampsia (PE), 
      placental abruption (PA) and atopy among offspring. METHOD OF STUDY: Obstetric 
      data was recorded from 378 women who were included into the Caesarean delivery 
      birth cohort during 1990-1992. When their children were 15-17 years old skin 
      prick tests (SPTs) and inhalant allergen-specific (IAS) immunoglobulin E (IgE) 
      were determined among offspring. RESULTS: Adolescents whose mothers had either PE 
      or PA at the time of delivery had more atopy and especially more severe atopy as 
      measured by the incidence of SPTs positive for > or = 5 allergens (RR: 4.28, 95% 
      CI: 1.54-11.92; P < 0.005) and elevated IAS IgE levels (> or = 1.0 kU/L) (RR: 
      4.27, 95% CI: 1.08-16.99; P < 0.039). This increased risk was particularly 
      observed in male adolescents. CONCLUSION: Maternal PE and PA were associated with 
      an increased risk of severe atopy, especially in male adolescent offspring.
FAU - Keski-Nisula, Leea
AU  - Keski-Nisula L
AD  - Department of Environmental Health, National Institute for Health and Welfare, 
      Kuopio, Finland. leea.keski-nisula@kuh.fi
FAU - Heinonen, Seppo
AU  - Heinonen S
FAU - Remes, Sami
AU  - Remes S
FAU - Pekkanen, Juha
AU  - Pekkanen J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Am J Reprod Immunol
JT  - American journal of reproductive immunology (New York, N.Y. : 1989)
JID - 8912860
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - *Abruptio Placentae
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Allergens/immunology
MH  - *Child of Impaired Parents
MH  - Female
MH  - Finland
MH  - Humans
MH  - Hypersensitivity, Immediate/blood/*congenital/diagnosis/immunology
MH  - Immunization
MH  - Immunoglobulin E/blood
MH  - Male
MH  - Mothers
MH  - *Pre-Eclampsia
MH  - Pregnancy
MH  - Risk Factors
MH  - Sex Factors
MH  - Skin Tests
EDAT- 2009/10/09 06:00
MHDA- 2010/05/18 06:00
CRDT- 2009/10/09 06:00
PHST- 2009/10/09 06:00 [entrez]
PHST- 2009/10/09 06:00 [pubmed]
PHST- 2010/05/18 06:00 [medline]
AID - AJI738 [pii]
AID - 10.1111/j.1600-0897.2009.00738.x [doi]
PST - ppublish
SO  - Am J Reprod Immunol. 2009 Nov;62(5):293-300. doi: 
      10.1111/j.1600-0897.2009.00738.x.