PMID- 19813623
OWN - NLM
STAT- MEDLINE
DCOM- 20111206
LR  - 20151119
IS  - 1001-5515 (Print)
IS  - 1001-5515 (Linking)
VI  - 26
IP  - 4
DP  - 2009 Aug
TI  - [Relationships of human laryngeal squamous cell carcinomas with the expression of 
      VEGF-C and VEGFR-3].
PG  - 842-6
AB  - In order to detect the relationships of human laryngeal squamous cell carcinoma 
      (LSCC) with the expression of Vascular Endothelial Growth Factor C (VEGF-C) and 
      Vascular Endothelial Growth Factor Receptor-3 (VEGFR-3), we examined the level of 
      VEGF-C and VEGFR-3 gene expression in the samples from 30 cases of normal 
      laryngeal mucosa tissue (NLM), primary laryngeal carcinoma (PLC) and cervical 
      lymph node (CLN) by using reverse transcription polymerase chain reaction 
      (RT-PCR). The protein levels of VEGF-C and VEGFR-3 expression were also 
      determined by Western blotting in 10 cases of NLM, PLC, CLN,respectively. We 
      found that in the samples from the same patient, the VEGF-C and VEGFR-3 
      expression level is different among normal laryngeal mucosa tissue, primary 
      laryngeal carcinoma and cervical lymph node. In primary laryngeal carcinoma, the 
      level of VEGF-C and VEGFR-3 expression was significantly higher in lymph node 
      positive group than in lymph node negative group, and this difference was the 
      associated with the histological grade of differentiation (P < 0.05). The 
      expression levels of VEGF-C and VEGFR-3 were not associated with age, sex, site 
      and T stage (P > 0.5). These results suggest that there is a close relationship 
      of LSCC with VEGF-C/VEGFR-3; and VEGF-C/VEGFR-3 may have the potential for use as 
      an indicator with prognostic significance in dealing with LSCC.
FAU - Wang, Zhongliang
AU  - Wang Z
AD  - Department of Otolaryngology, Subei People's Hospital of Jiangsu Province, 
      Yangzhou 225002, China.
FAU - Li, Ruixiang
AU  - Li R
FAU - Zhou, Bin
AU  - Zhou B
FAU - Liang, Weibo
AU  - Liang W
FAU - Liang, Chuanyu
AU  - Liang C
FAU - Zhang, Lin
AU  - Zhang L
FAU - Chen, Yao
AU  - Chen Y
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Sheng Wu Yi Xue Gong Cheng Xue Za Zhi
JT  - Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = 
      Shengwu yixue gongchengxue zazhi
JID - 9426398
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Vascular Endothelial Growth Factor C)
RN  - EC 2.7.10.1 (Vascular Endothelial Growth Factor Receptor-3)
SB  - IM
MH  - Aged
MH  - Biomarkers, Tumor/biosynthesis
MH  - Carcinoma, Squamous Cell/*metabolism
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Vascular Endothelial Growth Factor C/*metabolism
MH  - Vascular Endothelial Growth Factor Receptor-3/*metabolism
EDAT- 2009/10/10 06:00
MHDA- 2011/12/13 00:00
CRDT- 2009/10/10 06:00
PHST- 2009/10/10 06:00 [entrez]
PHST- 2009/10/10 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
PST - ppublish
SO  - Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2009 Aug;26(4):842-6.