PMID- 19816234
OWN - NLM
STAT- MEDLINE
DCOM- 20100302
LR  - 20091218
IS  - 1537-4505 (Electronic)
IS  - 1531-7129 (Linking)
VI  - 31
IP  - 1
DP  - 2010 Jan
TI  - Eosinophilic inflammation in the middle ear induces deterioration of 
      bone-conduction hearing level in patients with eosinophilic otitis media.
PG  - 100-4
LID - 10.1097/MAO.0b013e3181bc3781 [doi]
AB  - OBJECTIVE: Eosinophilic otitis media (EOM) is characterized by the extensive 
      accumulation of eosinophils in the middle ear mucosa and middle ear effusion and 
      is usually associated with bronchial asthma. Eosinophilic otitis media patients 
      show gradual or sudden deterioration of hearing. In our previous study, we 
      reported that high-tone loss was more frequently found and more severe in EOM 
      patients than in control patients with chronic otitis media. These findings 
      suggest that not only bacterial infection but also eosinophilic inflammation in 
      the middle ear may damage the inner ear. The present study was performed to 
      determine whether eosinophilic inflammation is indeed related to deterioration of 
      bone-conduction hearing level (BCHL). PATIENTS: Fifty-five ears of 28 patients 
      with EOM associated with bronchial asthma were included in this study. Middle ear 
      effusion (MEE) samples were collected from all the patients, and the 
      concentrations of eosinophilic cationic protein (ECP) and immunoglobulin E (IgE) 
      were measured by fluorescence enzyme immunoassay. The BCHLs at 2 and 4 kHz for 
      the worse-hearing ear of each patient were correlated with the concentrations of 
      ECP and IgE. RESULTS: The concentration of IgE in MEE significantly and 
      positively correlated with BCHL at 2 and 4 kHz. The ears with a higher 
      concentration of ECP in MEE also tended to show deterioration of BCHL at 4 kHz. 
      Other clinical risk factors for BCHL deterioration were male sex, long duration 
      of EOM, association with bacterial infection, severe inflammatory changes of the 
      middle ear mucosa, and high serum IgE concentration. CONCLUSION: 
      Eosinophilic-inflammation-related substances such as ECP and IgE are closely 
      related to the deterioration of BCHL at high frequencies. Particularly, IgE 
      concentration in MEE is a good indicator of BCHL elevation. We should always pay 
      attention to the hearing acuity of EOM patients with the risk factors.
FAU - Iino, Yukiko
AU  - Iino Y
AD  - Department of Otolaryngology, Jichi Medical University Saitama Medical Center, 
      Saitama, Japan. yiino@jichi.ac.jp
FAU - Usubuchi, Hajime
AU  - Usubuchi H
FAU - Kodama, Kozue
AU  - Kodama K
FAU - Kanazawa, Hiromi
AU  - Kanazawa H
FAU - Takizawa, Katsumi
AU  - Takizawa K
FAU - Kanazawa, Takeharu
AU  - Kanazawa T
FAU - Ohta, Yasushi
AU  - Ohta Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Otol Neurotol
JT  - Otology & neurotology : official publication of the American Otological Society, 
      American Neurotology Society [and] European Academy of Otology and Neurotology
JID - 100961504
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 3.1.27.- (Eosinophil Cationic Protein)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Audiometry, Pure-Tone
MH  - Auditory Threshold
MH  - Bone Conduction
MH  - Chronic Disease
MH  - Eosinophil Cationic Protein/analysis
MH  - Eosinophils/*metabolism
MH  - Exudates and Transudates/chemistry
MH  - Female
MH  - Hearing Loss/*etiology/metabolism
MH  - Humans
MH  - Immunoassay
MH  - Immunoglobulin E/analysis
MH  - Male
MH  - Middle Aged
MH  - Otitis Media with Effusion/*complications/metabolism
MH  - Regression Analysis
MH  - Severity of Illness Index
EDAT- 2009/10/10 06:00
MHDA- 2010/03/03 06:00
CRDT- 2009/10/10 06:00
PHST- 2009/10/10 06:00 [entrez]
PHST- 2009/10/10 06:00 [pubmed]
PHST- 2010/03/03 06:00 [medline]
AID - 10.1097/MAO.0b013e3181bc3781 [doi]
PST - ppublish
SO  - Otol Neurotol. 2010 Jan;31(1):100-4. doi: 10.1097/MAO.0b013e3181bc3781.