PMID- 19816710
OWN - NLM
STAT- MEDLINE
DCOM- 20100217
LR  - 20211020
IS  - 1432-2307 (Electronic)
IS  - 0945-6317 (Linking)
VI  - 455
IP  - 4
DP  - 2009 Oct
TI  - Atypical lipomatous tumors of the tongue: report of six cases.
PG  - 383-8
LID - 10.1007/s00428-009-0835-6 [doi]
AB  - The occurrence of liposarcoma in the tongue is rare with only 34 cases published 
      so far. We report six new cases of atypical lipomatous tumor (ALT) of the tongue, 
      and detection of mdm-2 and CDK4 expression by immunohistochemistry and 
      fluorescence in situ hybridization (FISH), respectively, was performed. The 
      series comprised three males and three females, aged 11-78 years. The tumors 
      arose at the lateral side of the tongue, and in one case, multiple tumor nodules 
      were noted. Follow-up information in five cases (range from 4 to 159 months) 
      revealed one local recurrence at 6 months. Microscopically, four cases had 
      features of lipoma-like ALT, whereas two cases displayed patterns of sclerosing 
      ALT. Immunohistochemically, tumor cells revealed expression of vimentin (five of 
      five), S100 (five of five), mdm-2 (three of five), and CDK4 (four of five). Two 
      cases were also examined by FISH; amplification of mdm-2 gene was found in both 
      cases, whereas amplification of CDK4 gene was present in one case only. To the 
      best of our knowledge, this is the third largest series reporting occurrence of 
      ALT in the tongue and the first one where analysis of mdm-2 and CDK4 
      proteins/genes expression/amplification was performed. Both these markers may be 
      of help in the differential diagnosis of ALT versus lipoma. Although most ALTs of 
      the tongue behave in the nonaggressive fashion, they may recur locally. Based on 
      current data, the term ALT is strongly recommended for tumors occurring in the 
      tongue to prevent inadequate treatment.
FAU - Laco, Jan
AU  - Laco J
AD  - The Fingerland Department of Pathology, Charles University Medical Faculty and 
      Faculty Hospital in Hradec Kralove, Hradec Kralove, Czech Republic. 
      lacoj@lfhk.cuni.cz
FAU - Mentzel, Thomas
AU  - Mentzel T
FAU - Hornychova, Helena
AU  - Hornychova H
FAU - Kohout, Ales
AU  - Kohout A
FAU - Jirousek, Zdenek
AU  - Jirousek Z
FAU - Ryska, Ales
AU  - Ryska A
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091009
PL  - Germany
TA  - Virchows Arch
JT  - Virchows Archiv : an international journal of pathology
JID - 9423843
RN  - 0 (S100 Proteins)
RN  - 0 (Vimentin)
RN  - EC 2.3.2.27 (MDM2 protein, human)
RN  - EC 2.3.2.27 (Proto-Oncogene Proteins c-mdm2)
RN  - EC 2.7.11.22 (CDK4 protein, human)
RN  - EC 2.7.11.22 (Cyclin-Dependent Kinase 4)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Child
MH  - Cyclin-Dependent Kinase 4/metabolism
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lipoma/*pathology
MH  - Liposarcoma/metabolism/*pathology
MH  - Male
MH  - Middle Aged
MH  - Proto-Oncogene Proteins c-mdm2/metabolism
MH  - S100 Proteins/metabolism
MH  - Tongue/pathology
MH  - Tongue Neoplasms/metabolism/*pathology
MH  - Vimentin/metabolism
EDAT- 2009/10/10 06:00
MHDA- 2010/02/18 06:00
CRDT- 2009/10/10 06:00
PHST- 2009/07/27 00:00 [received]
PHST- 2009/09/03 00:00 [accepted]
PHST- 2009/09/01 00:00 [revised]
PHST- 2009/10/10 06:00 [entrez]
PHST- 2009/10/10 06:00 [pubmed]
PHST- 2010/02/18 06:00 [medline]
AID - 10.1007/s00428-009-0835-6 [doi]
PST - ppublish
SO  - Virchows Arch. 2009 Oct;455(4):383-8. doi: 10.1007/s00428-009-0835-6. Epub 2009 
      Oct 9.