PMID- 1981749
OWN - NLM
STAT- MEDLINE
DCOM- 19910422
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 190
IP  - 1-2
DP  - 1990 Nov 6
TI  - Identification of the opioid receptor types mediating beta-endorphin-induced 
      alterations in dopamine release in the nucleus accumbens.
PG  - 177-84
AB  - In the present study we used in vivo microdialysis to examine the influence of 
      beta-endorphin on dopamine (DA) release in the nucleus accumbens of anesthetized 
      rats and to identify the opioid receptor types mediating its effects. 
      Microdialysis probes were inserted into the nucleus accumbens and perfusates were 
      analysed for DA and its metabolites, dihydroxyphenylacetic acid (DOPAC) and 
      homovanillic acid (HVA), using a reversed phase HPLC system with electrochemical 
      detection for separation and quantification. Intracerebroventricular (i.c.v.) 
      administration of beta-endorphin resulted in a dose-dependent increase in DA and 
      its metabolites. Pretreatment with the selective delta-antagonist ICI 174,864 
      significantly attenuated the beta-endorphin-induced increase in DA release and 
      metabolism whereas pretreatment with the selective mu-antagonist CTOP resulted 
      abolition of the beta-endorphin effect. These data demonstrate that the blockade 
      of either mu- or delta-opioid receptors is sufficient to antagonize the 
      stimulatory effects of beta-endorphin on DA release and metabolism. As such, 
      these findings suggest that the concomitant activation of both mu- and 
      delta-receptors underlies the effects of beta-endorphin on DA release in the 
      nucleus accumbens.
FAU - Spanagel, R
AU  - Spanagel R
AD  - Department of Neuropharmacology, Max-Planck-Institut fur Psychiatrie, 
      Martinsried, F.R.G.
FAU - Herz, A
AU  - Herz A
FAU - Shippenberg, T S
AU  - Shippenberg TS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Analgesics)
RN  - 0 (Biogenic Monoamines)
RN  - 0 (Enkephalins)
RN  - 0 (Narcotic Antagonists)
RN  - 0 (Receptors, Opioid)
RN  - 100929-53-1 (Enkephalin, Ala(2)-MePhe(4)-Gly(5)-)
RN  - 103429-31-8 
      (phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide)
RN  - 51110-01-1 (Somatostatin)
RN  - 58822-25-6 (Enkephalin, Leucine)
RN  - 60617-12-1 (beta-Endorphin)
RN  - 88373-73-3 (Enkephalin, D-Penicillamine (2,5)-)
RN  - 89352-67-0 (N,N-diallyl-tyrosyl-alpha-aminoisobutyric acid-phenylalanyl-leucine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Analgesics/pharmacology
MH  - Animals
MH  - Biogenic Monoamines/metabolism
MH  - Brain Chemistry/drug effects
MH  - Chromatography, High Pressure Liquid
MH  - Dialysis
MH  - Dopamine/*metabolism
MH  - Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
MH  - Enkephalin, D-Penicillamine (2,5)-
MH  - Enkephalin, Leucine/analogs & derivatives/pharmacology
MH  - Enkephalins/pharmacology
MH  - Injections, Intraventricular
MH  - Male
MH  - Narcotic Antagonists/pharmacology
MH  - Nucleus Accumbens/drug effects/*metabolism
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, Opioid/*physiology
MH  - Somatostatin/analogs & derivatives/pharmacology
MH  - beta-Endorphin/*pharmacology
EDAT- 1990/11/06 00:00
MHDA- 1990/11/06 00:01
CRDT- 1990/11/06 00:00
PHST- 1990/11/06 00:00 [pubmed]
PHST- 1990/11/06 00:01 [medline]
PHST- 1990/11/06 00:00 [entrez]
AID - 0014-2999(90)94124-G [pii]
AID - 10.1016/0014-2999(90)94124-g [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1990 Nov 6;190(1-2):177-84. doi: 10.1016/0014-2999(90)94124-g.