PMID- 19818376
OWN - NLM
STAT- MEDLINE
DCOM- 20100405
LR  - 20220409
IS  - 1872-8057 (Electronic)
IS  - 0303-7207 (Linking)
VI  - 316
IP  - 2
DP  - 2010 Mar 25
TI  - Ovarian function and obesity--interrelationship, impact on women's reproductive 
      lifespan and treatment options.
PG  - 172-9
LID - 10.1016/j.mce.2009.09.026 [doi]
AB  - Insulin resistance (IR) is a consequence of obesity, and in women it is often 
      inextricably linked with ovarian function leading to clinical reproductive 
      manifestations such as early menarche onset, subfertility and polycystic ovary 
      syndrome (PCOS). Likewise, the dramatic fall in oestrogen production after 
      menopause may contribute to weight gain and changes in adipose tissue 
      distribution. Overall, women who are obese, especially those with reproductive 
      complications including PCOS, have been identified as specific high risk 
      subgroups for further progression through to prediabetes, type 2 diabetes 
      mellitus (T2DM) and potentially cardiovascular disease (CVD). This review focuses 
      on the interrelationship between the ovarian function and obesity as well as its 
      treatment strategies.
CI  - 2009 Elsevier Ireland Ltd. All rights reserved.
FAU - Rachon, Dominik
AU  - Rachon D
AD  - Department of Clinical Nutrition, Medical University of Gdansk, Gdansk, Poland. 
      drachon@gumed.edu.pl
FAU - Teede, Helena
AU  - Teede H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20091007
PL  - Ireland
TA  - Mol Cell Endocrinol
JT  - Molecular and cellular endocrinology
JID - 7500844
RN  - 0 (Contraceptives, Oral)
SB  - IM
MH  - Animals
MH  - Cardiovascular Diseases/etiology/physiopathology
MH  - Contraceptives, Oral/therapeutic use
MH  - Diabetes Mellitus, Type 2/etiology/physiopathology
MH  - Disease Progression
MH  - Female
MH  - Hormone Replacement Therapy
MH  - Humans
MH  - Infertility/drug therapy/etiology/physiopathology
MH  - Insulin Resistance/*physiology
MH  - Menarche/physiology
MH  - Menopause/physiology
MH  - Obesity/complications/*physiopathology/surgery
MH  - Ovary/*physiology
MH  - Polycystic Ovary Syndrome/etiology/*physiopathology/therapy
MH  - Reproduction/*physiology
MH  - Risk Factors
MH  - Risk Reduction Behavior
MH  - *Women's Health
RF  - 121
EDAT- 2009/10/13 06:00
MHDA- 2010/04/07 06:00
CRDT- 2009/10/13 06:00
PHST- 2008/12/19 00:00 [received]
PHST- 2009/09/02 00:00 [revised]
PHST- 2009/09/28 00:00 [accepted]
PHST- 2009/10/13 06:00 [entrez]
PHST- 2009/10/13 06:00 [pubmed]
PHST- 2010/04/07 06:00 [medline]
AID - S0303-7207(09)00523-1 [pii]
AID - 10.1016/j.mce.2009.09.026 [doi]
PST - ppublish
SO  - Mol Cell Endocrinol. 2010 Mar 25;316(2):172-9. doi: 10.1016/j.mce.2009.09.026. 
      Epub 2009 Oct 7.