PMID- 19818873
OWN - NLM
STAT- MEDLINE
DCOM- 20100504
LR  - 20171116
IS  - 0006-3002 (Print)
IS  - 0006-3002 (Linking)
VI  - 1801
IP  - 3
DP  - 2010 Mar
TI  - Insulin resistance, lipotoxicity and endothelial dysfunction.
PG  - 320-6
LID - 10.1016/j.bbalip.2009.09.025 [doi]
AB  - The number of people with the insulin-resistant conditions of type 2 diabetes 
      mellitus (T2DM) and obesity has reached epidemic proportions worldwide. Eighty 
      percent of people with T2DM will die from the complications of cardiovascular 
      atherosclerosis. Insulin resistance is characterised by endothelial dysfunction, 
      which is a pivotal step in the initiation/progression of atherosclerosis. A 
      hallmark of endothelial dysfunction is an unfavourable imbalance between the 
      bioavailability of the antiatherosclerotic signalling molecule nitric oxide (NO) 
      and proatherosclerotic reactive oxygen species. In this review we discuss the 
      mechanisms linking insulin resistance to endothelial dysfunction, with a 
      particular emphasis on a potential role for a toxic effect of free fatty acids on 
      endothelial cell homeostasis.
CI  - Copyright (c) 2009 Elsevier B.V. All rights reserved.
FAU - Imrie, Helen
AU  - Imrie H
AD  - Division of Cardiovascular and Diabetes Research, Leeds Multidisciplinary 
      Cardiovascular Research Centre, The LIGHT Laboratories, Clarendon Way, Leeds, 
      LS29JT, UK. h.imrie@leeds.ac.uk
FAU - Abbas, Afroze
AU  - Abbas A
FAU - Kearney, Mark
AU  - Kearney M
LA  - eng
GR  - British Heart Foundation/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20091008
PL  - Netherlands
TA  - Biochim Biophys Acta
JT  - Biochimica et biophysica acta
JID - 0217513
RN  - 0 (Fatty Acids, Nonesterified)
RN  - 0 (Reactive Oxygen Species)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - EC 1.6.3.- (NADPH Oxidases)
SB  - IM
MH  - Animals
MH  - Dyslipidemias/metabolism
MH  - Endothelium, Vascular/*metabolism
MH  - Fatty Acids, Nonesterified/*metabolism
MH  - Humans
MH  - *Insulin Resistance
MH  - NADPH Oxidases/metabolism
MH  - Nitric Oxide/metabolism
MH  - Oxidative Stress
MH  - Reactive Oxygen Species/metabolism
MH  - Vascular Diseases/*metabolism
RF  - 83
EDAT- 2009/10/13 06:00
MHDA- 2010/05/05 06:00
CRDT- 2009/10/13 06:00
PHST- 2009/07/06 00:00 [received]
PHST- 2009/09/17 00:00 [revised]
PHST- 2009/09/30 00:00 [accepted]
PHST- 2009/10/13 06:00 [entrez]
PHST- 2009/10/13 06:00 [pubmed]
PHST- 2010/05/05 06:00 [medline]
AID - S1388-1981(09)00238-8 [pii]
AID - 10.1016/j.bbalip.2009.09.025 [doi]
PST - ppublish
SO  - Biochim Biophys Acta. 2010 Mar;1801(3):320-6. doi: 10.1016/j.bbalip.2009.09.025. 
      Epub 2009 Oct 8.