PMID- 19819281
OWN - NLM
STAT- MEDLINE
DCOM- 20100121
LR  - 20221207
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 71
IP  - 1
DP  - 2010 Jan
TI  - Association of human leukocyte antigen class II alleles with response to 
      immunosuppressive therapy in Korean aplastic anemia patients.
PG  - 88-92
LID - 10.1016/j.humimm.2009.10.002 [doi]
AB  - HLA-DR15 (DR2) is overrepresented in aplastic anemia (AA) patients, and its 
      presence is associated with a better response to cyclosporine-based 
      immunosuppressive therapy (IST). However, little is known about other human 
      leukocyte antigen (HLA) alleles affecting therapy response. We investigated 37 
      Korean patients with severe AA for the association of HLA class II alleles with 
      response to IST: cyclosporine A combined with antithymocyte globulin or 
      antilymphocyte globulin. Molecular or serologic typing of HLA-DR and HLA-DQ 
      alleles was performed. In responders (13/37, 35.1%), the frequency of HLA-DR15 
      was increased (69.2% vs 8.3%, p = 0.0002) and that of DR4 was decreased (7.7% vs 
      66.7%, p = 0.0007) compared with nonresponders. The response rate was 
      significantly higher in DR15(+) than in DR15(-) (81.8% vs 15.4%, p = 0.0002) and 
      in DR4(-) than in DR4(+) patients (60.0% vs 5.9%, p = 0.0007). The response rates 
      in the best (DR15(+)/DR4(-)), intermediate, and poor response groups 
      (DR15(-)/DR4(+)) were 88.9, 38.5, and 0%, respectively (p = 0.00001). At the 
      allelic level, DRB1*1501 and closely linked DQB1*0602 were associated with a good 
      response and DRB1*0405 and closely linked DQB1*0401 with a poor response to IST. 
      HLA-DR typing may be useful for predicting a response to IST in AA patients.
FAU - Song, Eun Young
AU  - Song EY
AD  - Department of Laboratory Medicine, Seoul National University College of Medicine, 
      Seoul, Korea.
FAU - Kang, Hyoung Jin
AU  - Kang HJ
FAU - Shin, Hee Young
AU  - Shin HY
FAU - Ahn, Hyo Seop
AU  - Ahn HS
FAU - Kim, Inho
AU  - Kim I
FAU - Yoon, Sung-Soo
AU  - Yoon SS
FAU - Park, Seonyang
AU  - Park S
FAU - Kim, Byoung Kook
AU  - Kim BK
FAU - Park, Myoung Hee
AU  - Park MH
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Antilymphocyte Serum)
RN  - 0 (HLA-D Antigens)
RN  - 0 (Immunosuppressive Agents)
RN  - 83HN0GTJ6D (Cyclosporine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Anemia, Aplastic/drug therapy/*genetics/*immunology
MH  - Antilymphocyte Serum/therapeutic use
MH  - Asian People/*genetics
MH  - Child
MH  - Child, Preschool
MH  - Cyclosporine/therapeutic use
MH  - Female
MH  - HLA-D Antigens/*genetics/immunology
MH  - Humans
MH  - Immunosuppressive Agents/*therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Young Adult
EDAT- 2009/10/13 06:00
MHDA- 2010/01/22 06:00
CRDT- 2009/10/13 06:00
PHST- 2009/04/21 00:00 [received]
PHST- 2009/09/11 00:00 [revised]
PHST- 2009/10/02 00:00 [accepted]
PHST- 2009/10/13 06:00 [entrez]
PHST- 2009/10/13 06:00 [pubmed]
PHST- 2010/01/22 06:00 [medline]
AID - S0198-8859(09)00609-0 [pii]
AID - 10.1016/j.humimm.2009.10.002 [doi]
PST - ppublish
SO  - Hum Immunol. 2010 Jan;71(1):88-92. doi: 10.1016/j.humimm.2009.10.002.