PMID- 19820376
OWN - NLM
STAT- MEDLINE
DCOM- 20091229
LR  - 20181030
IS  - 1525-1438 (Electronic)
IS  - 1048-891X (Linking)
VI  - 19
IP  - 6
DP  - 2009 Aug
TI  - Human leukocyte antigens I and II haplotypes associated with human papillomavirus 
      16-positive invasive cervical cancer in Mexican women.
PG  - 1099-106
LID - 10.1111/IGC.0b013e3181a83cf4 [doi]
AB  - Infection with human papillomavirus (HPV), mainly HPV type 16, is the major 
      etiologic factor associated with cervical cancer (CC), but HPV infection alone is 
      not sufficient for progression of precursor lesions. Host genetic susceptibility 
      may lead to abnormal immune response resulting from virus persistence. Several 
      studies have suggested a possible association with specific human leukocyte 
      antigen (HLA) class I and II alleles and CC, but results are not consistent. The 
      association of genetic HLA class I (A and B) and HLA class II (DR*B1 and DQ*B1) 
      haplotypes with HPV16-positive CC (n = 104) and base population controls (n = 
      104) was evaluated in this Mexican population study. Sequence-specific primer HLA 
      genes were determined by polymerase chain reaction (PCR)-based methods in 
      peripheral blood cell counts (PCR sequence-specific oligonucleotides). The 
      cervical swabs of 208 women were tested for HPV16 by Hybrid Capture II. Allele 
      and haplotype HLA frequencies, Hardy-Weinberg tests, and a haplotype homogeneity 
      test were estimated using the Arlequin software v. 3.01. Odds ratio (OR) was 
      calculated to compare cases and control women. Consistent associations across 
      other studies in women with CC and infected by HPV16 were observed for 
      HLA-DRB1*15 (OR, 3.9; 95% CI, 1.6-10.2) and the haplotype DRB1*15 DQB1*0602 (OR, 
      4.1; 95% CI, 1.4-12.7) compared with control women. The HLA-A2-B44-DR4-DQ*0302, 
      HLA-A24-B35-DR16-DQ*0301, and HLA-A2-B40-DR4-DQ*0302 haplotypes showed a positive 
      association with CC (OR, >1), whereas HLA-A2-B39-DR4-DQ*0302, 
      HLA-A24-B35-DR4-DQ*0302, and HLA-A68-B40-DR4-DQ*0302 showed a negative 
      association (OR, <1). These results support the hypothesis that some HLA class I 
      and II haplotypes could be involved with susceptibility for developing CC.
FAU - Hernandez-Hernandez, Dulce M
AU  - Hernandez-Hernandez DM
AD  - Department of Epidemiology, Medical Research Unit in Oncology Diseases, 
      Epidemiological Research and Health Services Unit Oncology Hospital, Centro 
      Medico Siglo XXI, Instituto Mexicano del Seguro Social, Av Cuauhtemoc 330, Mexico 
      City, Mexico. dulcema@servidor.unam.mx
FAU - Cerda-Flores, Ricardo M
AU  - Cerda-Flores RM
FAU - Juarez-Cedillo, Teresa
AU  - Juarez-Cedillo T
FAU - Granados-Arriola, Julio
AU  - Granados-Arriola J
FAU - Vargas-Alarcon, Gilberto
AU  - Vargas-Alarcon G
FAU - Apresa-Garcia, Teresa
AU  - Apresa-Garcia T
FAU - Alvarado-Cabrero, Isabel
AU  - Alvarado-Cabrero I
FAU - Garcia-Carranca, Alejandro
AU  - Garcia-Carranca A
FAU - Salcedo-Vargas, Mauricio
AU  - Salcedo-Vargas M
FAU - Mohar-Betancourt, Alejandro
AU  - Mohar-Betancourt A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Gynecol Cancer
JT  - International journal of gynecological cancer : official journal of the 
      International Gynecological Cancer Society
JID - 9111626
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma/*genetics/pathology/virology
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Haplotypes
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Histocompatibility Antigens Class II/*genetics
MH  - *Human papillomavirus 16/genetics
MH  - Humans
MH  - Mexico
MH  - Middle Aged
MH  - Neoplasm Invasiveness
MH  - Papillomavirus Infections/complications/genetics
MH  - Polymorphism, Genetic
MH  - Uterine Cervical Neoplasms/*genetics/pathology/virology
EDAT- 2009/10/13 06:00
MHDA- 2009/12/30 06:00
CRDT- 2009/10/13 06:00
PHST- 2009/10/13 06:00 [entrez]
PHST- 2009/10/13 06:00 [pubmed]
PHST- 2009/12/30 06:00 [medline]
AID - 00009577-200908000-00020 [pii]
AID - 10.1111/IGC.0b013e3181a83cf4 [doi]
PST - ppublish
SO  - Int J Gynecol Cancer. 2009 Aug;19(6):1099-106. doi: 10.1111/IGC.0b013e3181a83cf4.