PMID- 19820810
OWN - NLM
STAT- MEDLINE
DCOM- 20100507
LR  - 20190608
IS  - 1806-3756 (Electronic)
IS  - 1806-3713 (Linking)
VI  - 35
IP  - 9
DP  - 2009 Sep
TI  - Factors associated with the minimal clinically important difference for 
      health-related quality of life after physical conditioning in patients with COPD.
PG  - 846-53
LID - S1806-37132009000900005 [pii]
AB  - OBJECTIVE: To identify factors associated with the minimal clinically important 
      difference (MCID) for health-related quality of life (HRQoL) after physical 
      conditioning in patients with COPD. METHODS: Thirty-five patients were submitted 
      to a 12-week program of physical conditioning (strength training plus 
      low-intensity aerobic exercise). Body composition, incremental treadmill test 
      results, endurance treadmill test results, six-minute walk test results, 
      peripheral muscle strength, MIP, baseline dyspnea index (BDI) and Saint George's 
      Respiratory Questionnaire (SGRQ) scores were assessed at baseline and after the 
      program, thus allowing the variations (Delta) to be calculated. The MCID for 
      HRQoL was defined as a reduction of > 4% in the SGRQ total score. Subjects who 
      responded to the program, achieving the MCID for HRQoL, were allocated to the 
      responders (R) group (n = 24), and the remainder were allocated to the 
      non-responders (NR) group (n = 11). RESULTS: The values obtained for the 
      following variables were significantly higher in group R than in group NR (p < 
      0.05): FEV1 (1.48 + or - 0.54 L vs. 1.04 + or - 0.34 L); VEF1/FVC (47.9 + or - 
      11.7% vs. 35.5 + or - 10.7%); PaO2 (74.1 + or - 9.7 mmHg vs. 65.0 + or - 8.9 
      mmHg); and DeltaBDI, expressed as median and interquartile range (2.0 [0.0-3.5] 
      vs. 0.0 [0.0-1.0]). The DeltaBDI correlated significantly with the DeltaSGRQ 
      symptoms domain score, activity domain score and total score (r = 0.44, 0.60 and 
      0.62, respectively, p < 0.01 for all). After logistic regression, only DeltaBDI 
      remained as a predictor of MCID for HRQoL. CONCLUSIONS: Achieving the MCID for 
      HRQoL after physical conditioning is associated with dyspnea reduction in COPD 
      patients. Therefore, there is a need to develop treatment strategies designed to 
      interrupt the dyspnea-inactivity-dyspnea cycle in such patients.
FAU - Dourado, Victor Zuniga
AU  - Dourado VZ
AD  - Universidade Federal de Sao Paulo, Santos, SP, Brasil. vzdourado@yahoo.com.br
FAU - Antunes, Leticia Claudia de Oliveira
AU  - Antunes LC
FAU - Tanni, Suzana Erico
AU  - Tanni SE
FAU - Godoy, Irma
AU  - Godoy I
LA  - eng
LA  - por
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - Brazil
TA  - J Bras Pneumol
JT  - Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de 
      Pneumologia e Tisilogia
JID - 101222274
SB  - IM
MH  - Dyspnea/physiopathology
MH  - Exercise/*physiology
MH  - Exercise Test
MH  - Female
MH  - *Health Status
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Pulmonary Disease, Chronic Obstructive/metabolism/*rehabilitation
MH  - *Quality of Life
EDAT- 2009/10/13 06:00
MHDA- 2010/05/08 06:00
CRDT- 2009/10/13 06:00
PHST- 2009/02/16 00:00 [received]
PHST- 2009/05/21 00:00 [accepted]
PHST- 2009/10/13 06:00 [entrez]
PHST- 2009/10/13 06:00 [pubmed]
PHST- 2010/05/08 06:00 [medline]
AID - S1806-37132009000900005 [pii]
AID - 10.1590/s1806-37132009000900005 [doi]
PST - ppublish
SO  - J Bras Pneumol. 2009 Sep;35(9):846-53. doi: 10.1590/s1806-37132009000900005.