PMID- 19820939
OWN - NLM
STAT- MEDLINE
DCOM- 20100804
LR  - 20211020
IS  - 1432-1963 (Electronic)
IS  - 0172-8113 (Linking)
VI  - 30 Suppl 2
DP  - 2009 Dec
TI  - [Cytology of the urinary tract: Between uncertainty and clarity].
PG  - 173-8
LID - 10.1007/s00292-009-1190-8 [doi]
AB  - Reliable detection of poorly differentiated urothelial carcinoma and the 
      detection of carcinoma in situ, which is often invisible by cystoscopy, are the 
      undisputed strength of urinary cytology. In contrast, well-differentiated 
      urothelial tumors are often missed by cytology. We suggest the following 
      classification: negative, questionable, suspicious, and positive. Due to the 
      complex clinico-pathological associations, the classification should always be 
      accompanied by an appropriate commentary. The WHO 2004 classification separates 
      the clinically less important low-grade tumors from the clinically relevant 
      high-grade tumors, usually classified as "positive" by cytology. A cytological 
      diagnosis of low-grade tumors by cytology is of minor clinical importance. Most 
      urothelial neoplasias are characterized by chromosomal aberrations. This makes 
      multi-target fluorescence in situ hybridization (FISH) assay suitable for the 
      clarification of non-definitive cytology. In contrast, positive cytology does not 
      need further confirmation by FISH analysis. Standardized diagnosis and the 
      possibility for supplementary analyses increase the diagnostic value of urinary 
      cytology.
FAU - Bubendorf, L
AU  - Bubendorf L
AD  - Institut fur Pathologie, Universitatsspital Basel, Schonbeinstr 40, 4003 Basel, 
      Schweiz. lbubendorf@uhbs.ch
FAU - Dalquen, P
AU  - Dalquen P
FAU - Savic, S
AU  - Savic S
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Zytologie der ableitenden Harnwege: Zwischen Zweifel und Gewissheit.
PL  - Germany
TA  - Pathologe
JT  - Der Pathologe
JID - 8006541
SB  - IM
MH  - Carcinoma in Situ/genetics/*pathology
MH  - Carcinoma, Transitional Cell/genetics/*pathology
MH  - Chromosome Aberrations
MH  - Cystoscopy
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Neoplasm Invasiveness/pathology
MH  - Urinary Bladder/pathology
MH  - Urinary Bladder Neoplasms/genetics/*pathology
MH  - Urine/cytology
RF  - 22
EDAT- 2009/10/13 06:00
MHDA- 2010/08/05 06:00
CRDT- 2009/10/13 06:00
PHST- 2009/10/13 06:00 [entrez]
PHST- 2009/10/13 06:00 [pubmed]
PHST- 2010/08/05 06:00 [medline]
AID - 10.1007/s00292-009-1190-8 [doi]
PST - ppublish
SO  - Pathologe. 2009 Dec;30 Suppl 2:173-8. doi: 10.1007/s00292-009-1190-8.