PMID- 19821770
OWN - NLM
STAT- MEDLINE
DCOM- 20100914
LR  - 20161125
IS  - 1523-4681 (Electronic)
IS  - 0884-0431 (Linking)
VI  - 25
IP  - 4
DP  - 2010 Apr
TI  - Association with replication between estrogen-related receptor gamma (ESRRgamma) 
      polymorphisms and bone phenotypes in women of European ancestry.
PG  - 901-11
LID - 10.1359/jbmr.091014 [doi]
AB  - Osteoporosis is a bone disease characterized by low bone mineral density (BMD), a 
      highly heritable polygenic trait. Women are more prone than men to develop 
      osteoporosis owing to a lower peak bone mass and accelerated bone loss at 
      menopause. Lack of estrogen thus is a major risk factor for osteoporosis. In 
      addition to having strong similarity to the estrogen receptor 1 (ESR1), the 
      orphan nuclear estrogen-related receptor gamma (ESRRgamma) is widely expressed 
      and shows overlap with ESR1 expression in tissues where estrogen has important 
      physiologic functions. For these reasons, we have undertaken a study of ESRRgamma 
      sequence variants in association with bone measurements [heel quantitative 
      ultrasound (QUS) by measurements of broadband ultrasound attenuation (BUA), speed 
      of sound (SOS), and stiffness index (SI) and dual-energy X-ray absorptiometry 
      (DXA) at the femoral neck (FN) and lumbar spine (LS)]. A silent variant was found 
      to be associated with multiple bone measurements (LS, BUA, SOS, and SI), the p 
      values ranging from .006 to .04 in a sample of 5144 Quebec women. The region of 
      this variant was analyzed using the HapMap database and the Gabriel method to 
      define a block of 20 kb. Using the Tagger method, eight TagSNPs were identified 
      and genotyped in a sample of 1335 women. Four of these SNPs capture the five 
      major block haplotypes. One SNP (rs2818964) and one haplotype were significantly 
      associated with multiple bone measures. All SNPs involved in the associations 
      were analyzed in two other sample sets with significant results in the same 
      direction. These results suggest involvement of ESRRgamma in the determination of 
      bone density in women.
CI  - Copyright 2010 American Society for Bone and Mineral Research.
FAU - Elfassihi, Latifa
AU  - Elfassihi L
AD  - Centre de Recherche de l'Hopital St-Francois d'Assise du Centre Hospitalier 
      Universitaire de Quebec, Quebec, Canada.
FAU - Giroux, Sylvie
AU  - Giroux S
FAU - Bureau, Alexandre
AU  - Bureau A
FAU - Laflamme, Nathalie
AU  - Laflamme N
FAU - Cole, David Ec
AU  - Cole DE
FAU - Rousseau, Francois
AU  - Rousseau F
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Bone Miner Res
JT  - Journal of bone and mineral research : the official journal of the American 
      Society for Bone and Mineral Research
JID - 8610640
RN  - 0 (ESRRG protein, human)
RN  - 0 (Receptors, Estrogen)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Bone Density/*genetics
MH  - Estrogen Replacement Therapy
MH  - Female
MH  - Femur Neck/diagnostic imaging/pathology
MH  - Genetic Association Studies/statistics & numerical data
MH  - *Genetic Predisposition to Disease
MH  - Haplotypes
MH  - Heel/diagnostic imaging/pathology
MH  - Humans
MH  - Lumbar Vertebrae/diagnostic imaging/pathology
MH  - Middle Aged
MH  - Ontario/epidemiology
MH  - Osteoporosis/diagnostic imaging/*epidemiology/*genetics
MH  - Phenotype
MH  - Polymorphism, Genetic
MH  - Polymorphism, Single Nucleotide
MH  - Quebec/epidemiology
MH  - Receptors, Estrogen/*genetics
MH  - Ultrasonography
EDAT- 2009/10/14 06:00
MHDA- 2010/09/15 06:00
CRDT- 2009/10/14 06:00
PHST- 2009/10/14 06:00 [entrez]
PHST- 2009/10/14 06:00 [pubmed]
PHST- 2010/09/15 06:00 [medline]
AID - 10.1359/jbmr.091014 [doi]
PST - ppublish
SO  - J Bone Miner Res. 2010 Apr;25(4):901-11. doi: 10.1359/jbmr.091014.