PMID- 19822147
OWN - NLM
STAT- MEDLINE
DCOM- 20091203
LR  - 20230519
IS  - 1873-3468 (Electronic)
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 583
IP  - 21
DP  - 2009 Nov 3
TI  - Radioprotection by short-term oxidative preconditioning: role of manganese 
      superoxide dismutase.
PG  - 3437-42
LID - 10.1016/j.febslet.2009.10.013 [doi]
AB  - Manganese superoxide dismutase (MnSOD) is vital to the protection of mitochondria 
      and cells against oxidative stress. Earlier, we demonstrated that catalytically 
      active homo-tetramer of MnSOD can be stabilized by oxidative cross-linking. Here 
      we report that this effect may be translated into increased radioresistance of 
      mouse embryonic cells (MECs) by pre-exposure to oxidative stress. Pre-treatment 
      of MECs with antimycin A, rotenone or H(2)O(2) increased their survival after 
      irradiation. Using MnSOD siRNA, we show that MECs with decreased MnSOD levels 
      displayed a lowered ability to preconditioning. Thus oxidative preconditioning 
      may be used for targeted regulation of MnSOD.
FAU - Belikova, Natalia A
AU  - Belikova NA
AD  - Department of Environmental and Occupational Health, University of Pittsburgh, 
      Pittsburgh, PA 15219, USA.
FAU - Glumac, Ashley
AU  - Glumac A
FAU - Rafikov, Ruslan
AU  - Rafikov R
FAU - Jiang, Jianfei
AU  - Jiang J
FAU - Greenberger, Joel S
AU  - Greenberger JS
FAU - Kagan, Valerian E
AU  - Kagan VE
FAU - Bayir, Hulya
AU  - Bayir H
LA  - eng
GR  - U19 AI068021-020002/AI/NIAID NIH HHS/United States
GR  - NS061817/NS/NINDS NIH HHS/United States
GR  - U19 AI068021-050002/AI/NIAID NIH HHS/United States
GR  - R01 HL070755-04/HL/NHLBI NIH HHS/United States
GR  - U19 AI068021-040002/AI/NIAID NIH HHS/United States
GR  - R01 HL070755-05/HL/NHLBI NIH HHS/United States
GR  - R01 HL070755-02/HL/NHLBI NIH HHS/United States
GR  - R01 NS061817/NS/NINDS NIH HHS/United States
GR  - HL70755/HL/NHLBI NIH HHS/United States
GR  - R01 HL070755-03/HL/NHLBI NIH HHS/United States
GR  - R01 HL070755/HL/NHLBI NIH HHS/United States
GR  - R01 NS061817-02/NS/NINDS NIH HHS/United States
GR  - U19 AI068021/AI/NIAID NIH HHS/United States
GR  - U19 AI068021-030002/AI/NIAID NIH HHS/United States
GR  - R37 NS061817/NS/NINDS NIH HHS/United States
GR  - R01 HL070755-06/HL/NHLBI NIH HHS/United States
GR  - R01 HL070755-01/HL/NHLBI NIH HHS/United States
GR  - U19 AI068021-010002/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20091012
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Reactive Oxygen Species)
RN  - 03L9OT429T (Rotenone)
RN  - 642-15-9 (Antimycin A)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - EC 7.1.1.2 (Electron Transport Complex I)
RN  - EC 7.1.1.8 (Electron Transport Complex III)
SB  - IM
MH  - Animals
MH  - Antimycin A/pharmacology
MH  - Cell Death/drug effects/radiation effects
MH  - Electron Transport Complex I/antagonists & inhibitors
MH  - Electron Transport Complex III/antagonists & inhibitors
MH  - Embryo, Mammalian/cytology
MH  - Mice
MH  - Oxidative Stress/*drug effects/*radiation effects
MH  - Reactive Oxygen Species/pharmacology
MH  - Rotenone/pharmacology
MH  - Superoxide Dismutase/*metabolism
MH  - Time Factors
PMC - PMC2784259
MID - NIHMS151948
EDAT- 2009/10/14 06:00
MHDA- 2009/12/16 06:00
PMCR- 2010/11/03
CRDT- 2009/10/14 06:00
PHST- 2009/08/12 00:00 [received]
PHST- 2009/09/03 00:00 [revised]
PHST- 2009/10/06 00:00 [accepted]
PHST- 2009/10/14 06:00 [entrez]
PHST- 2009/10/14 06:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
PHST- 2010/11/03 00:00 [pmc-release]
AID - S0014-5793(09)00784-4 [pii]
AID - 10.1016/j.febslet.2009.10.013 [doi]
PST - ppublish
SO  - FEBS Lett. 2009 Nov 3;583(21):3437-42. doi: 10.1016/j.febslet.2009.10.013. Epub 
      2009 Oct 12.