PMID- 19822203
OWN - NLM
STAT- MEDLINE
DCOM- 20100423
LR  - 20211020
IS  - 1090-2139 (Electronic)
IS  - 0889-1591 (Print)
IS  - 0889-1591 (Linking)
VI  - 24
IP  - 2
DP  - 2010 Feb
TI  - Repeated social stress enhances the innate immune response to a primary HSV-1 
      infection in the cornea and trigeminal ganglia of Balb/c mice.
PG  - 273-80
LID - 10.1016/j.bbi.2009.10.003 [doi]
AB  - Three to 5 days after a primary HSV-1 infection, macrophages infiltrate into the 
      trigeminal ganglia (TG) and produce anti-viral cytokines to reduce viral 
      replication. Previous research demonstrated that social disruption stress (SDR) 
      enhances the trafficking of monocytes/macrophages from the bone marrow to the 
      spleen and increases pro-inflammatory cytokine production in vitro and in vivo. 
      The impact of SDR on the trafficking of these cells to loci of herpes simplex 
      virus type 1 (HSV-1) infection and subsequent function has not been examined. The 
      following studies were designed to determine whether SDR would enhance the innate 
      immune response during a primary HSV-1 infection by increasing the number of 
      macrophages in the cornea and TG, thus increasing anti-viral cytokine production 
      and reducing viral replication. BALB/c mice were exposed to six cycles of SDR 
      prior to ocular infection with HSV-1 McKrae virus. Flow cytometric analysis of 
      cells from the TG revealed an increase in the percentage of CD11b+ macrophages in 
      SDR mice compared to controls. Immune cell infiltration into the cornea, however, 
      could not be determined due to low cell numbers. Although gene expression of 
      IFN-beta was decreased, SDR increased gene expression of IFN-alpha, and 
      TNF-alpha, in the cornea and TG. Examination of viral proteins showed decreased 
      expression of infected cell protein 0 (ICP0), glycoprotein B (gB), glycoprotein H 
      (gH) and latency-associated transcript (LAT) in the TG, however, expression of 
      ICP0 and gB were elevated in the cornea of SDR mice. These results indicate that 
      the innate immune response to HSV-1 was altered and enhanced by the experience of 
      repeated social defeat.
CI  - Copyright 2009 Elsevier Inc. All rights reserved.
FAU - Dong-Newsom, P
AU  - Dong-Newsom P
AD  - The Ohio State University, College of Dentistry, Section of Oral Biology, 
      Genetics, Columbus, OH 43210, USA.
FAU - Powell, N D
AU  - Powell ND
FAU - Bailey, M T
AU  - Bailey MT
FAU - Padgett, D A
AU  - Padgett DA
FAU - Sheridan, J F
AU  - Sheridan JF
LA  - eng
GR  - T32 DE014320-07/DE/NIDCR NIH HHS/United States
GR  - R01 MH046801/MH/NIMH NIH HHS/United States
GR  - R01MH046801-18/MH/NIMH NIH HHS/United States
GR  - T32DE014320-07/DE/NIDCR NIH HHS/United States
GR  - T32 DE014320/DE/NIDCR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20091012
PL  - Netherlands
TA  - Brain Behav Immun
JT  - Brain, behavior, and immunity
JID - 8800478
RN  - 0 (CD11b Antigen)
RN  - 0 (Cytokines)
RN  - 0 (Viral Proteins)
RN  - 63231-63-0 (RNA)
SB  - IM
MH  - Animals
MH  - CD11b Antigen/metabolism
MH  - Cornea/*immunology/metabolism/*virology
MH  - Cytokines/biosynthesis
MH  - Flow Cytometry
MH  - Gene Expression/physiology
MH  - Herpes Simplex/*immunology/*psychology/virology
MH  - *Herpesvirus 1, Human
MH  - Immunity, Innate/*physiology
MH  - Macrophages/metabolism/physiology
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - RNA/biosynthesis/isolation & purification
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - *Social Environment
MH  - Stress, Psychological/*immunology
MH  - Trigeminal Ganglion/*immunology/metabolism/*virology
MH  - Viral Proteins/biosynthesis/genetics
PMC - PMC2818401
MID - NIHMS157544
EDAT- 2009/10/14 06:00
MHDA- 2010/04/24 06:00
PMCR- 2011/02/01
CRDT- 2009/10/14 06:00
PHST- 2009/06/15 00:00 [received]
PHST- 2009/09/22 00:00 [revised]
PHST- 2009/10/05 00:00 [accepted]
PHST- 2009/10/14 06:00 [entrez]
PHST- 2009/10/14 06:00 [pubmed]
PHST- 2010/04/24 06:00 [medline]
PHST- 2011/02/01 00:00 [pmc-release]
AID - S0889-1591(09)00467-X [pii]
AID - 10.1016/j.bbi.2009.10.003 [doi]
PST - ppublish
SO  - Brain Behav Immun. 2010 Feb;24(2):273-80. doi: 10.1016/j.bbi.2009.10.003. Epub 
      2009 Oct 12.