PMID- 1982264
OWN - NLM
STAT- MEDLINE
DCOM- 19910521
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 191
IP  - 2
DP  - 1990 Nov 27
TI  - Chloral hydrate anesthesia antagonizes the neurotoxicity of 
      3,4-methylenedioxymethamphetamine.
PG  - 213-6
AB  - We report that maintaining rats under chloral hydrate anesthesia for the first 3 
      h following the administration of 3,4-methylenedioxymethamphetamine (MDMA) blocks 
      the decrease in forebrain concentrations of 5-hydroxytryptamine (5-HT) measured 1 
      week later. In contrast, the acute effect of MDMA (3 h) on forebrain 5-HT was not 
      altered by the anesthetic. This protective effect of chloral hydrate was not due 
      to an anesthetic-induced hypothermia but may be related to the hypothesized role 
      of dopamine in the neurotoxic effects of MDMA.
FAU - Schmidt, C J
AU  - Schmidt CJ
AD  - Merrell Dow Research Institute, Cincinnati, OH 45215.
FAU - Black, C K
AU  - Black CK
FAU - Abbate, G M
AU  - Abbate GM
FAU - Taylor, V L
AU  - Taylor VL
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 333DO1RDJY (Serotonin)
RN  - 418M5916WG (Chloral Hydrate)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/*analogs & derivatives/antagonists & 
      inhibitors/toxicity
MH  - *Anesthesia
MH  - Animals
MH  - Cerebral Cortex/cytology/*drug effects/metabolism
MH  - Chloral Hydrate/*pharmacology
MH  - Hippocampus/cytology/*drug effects/metabolism
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Premedication
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Serotonin/*metabolism
EDAT- 1990/11/27 00:00
MHDA- 1990/11/27 00:01
CRDT- 1990/11/27 00:00
PHST- 1990/11/27 00:00 [pubmed]
PHST- 1990/11/27 00:01 [medline]
PHST- 1990/11/27 00:00 [entrez]
AID - 0014-2999(90)94149-R [pii]
AID - 10.1016/0014-2999(90)94149-r [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1990 Nov 27;191(2):213-6. doi: 10.1016/0014-2999(90)94149-r.