PMID- 1982265
OWN - NLM
STAT- MEDLINE
DCOM- 19910521
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 191
IP  - 2
DP  - 1990 Nov 27
TI  - Effects of methylenedioxymethamphetamine on the release of monoamines from rat 
      brain slices.
PG  - 217-20
AB  - The effects of 3,4-methylenedioxymethamphetamine (MDMA) on monoamine release were 
      investigated in superfused slices of rat striatum and hippocampus. MDMA (10 
      microM) increased the resting release of radioactivity from slices incubated in 
      [3H]dopamine, [3H]5-hydroxytryptamine or [3H]noradrenaline. These effects of MDMA 
      (10 microM) were blocked by the neuronal uptake inhibitors, cocaine (10 microM), 
      fluoxetine (1 microM) and desmethylimipramine (1 microM), respectively. MDMA (10 
      microM) enhanced the stimulation-induced efflux of radioactivity from slices 
      incubated in [3H]noradrenaline but not from slices incubated in 
      [3H]5-hydroxytryptamine or [3H]dopamine. These results demonstrate for the first 
      time a direct noradrenaline-releasing action of MDMA and differential effects of 
      MDMA on the stimulation-induced release of noradrenaline, dopamine and 
      5-hydroxytryptamine from rat superfused brain slices.
FAU - Fitzgerald, J L
AU  - Fitzgerald JL
AD  - Department of Pharmacology, University of Melbourne, Victoria, Australia.
FAU - Reid, J J
AU  - Reid JJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 333DO1RDJY (Serotonin)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - VTD58H1Z2X (Dopamine)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/*analogs & derivatives/pharmacology
MH  - Animals
MH  - Corpus Striatum/*metabolism
MH  - Dopamine/*metabolism
MH  - Electric Stimulation
MH  - Female
MH  - Hippocampus/*metabolism
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Norepinephrine/*metabolism
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Serotonin/*metabolism
EDAT- 1990/11/27 00:00
MHDA- 1990/11/27 00:01
CRDT- 1990/11/27 00:00
PHST- 1990/11/27 00:00 [pubmed]
PHST- 1990/11/27 00:01 [medline]
PHST- 1990/11/27 00:00 [entrez]
AID - 0014-2999(90)94150-V [pii]
AID - 10.1016/0014-2999(90)94150-v [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1990 Nov 27;191(2):217-20. doi: 10.1016/0014-2999(90)94150-v.