PMID- 1982341
OWN - NLM
STAT- MEDLINE
DCOM- 19910520
LR  - 20190726
IS  - 0028-3908 (Print)
IS  - 0028-3908 (Linking)
VI  - 29
IP  - 11
DP  - 1990 Nov
TI  - Diminished corticotropin and enhanced prolactin responses to 
      8-hydroxy-2(di-n-propylamino)tetralin in methylenedioxymethamphetamine pretreated 
      rats.
PG  - 1099-101
AB  - Although (+/-) methylenedioxymethamphetamine (MDMA) has been reported to deplete 
      serotonin (5-HT) and destroy 5-HT terminals in the brains of animals, the 
      functional sequelae of such alterations remain to be established. In the present 
      study, a blunted corticotropin and an enhanced prolactin response to the 5-HT1A 
      agonist 8-hydroxy-2(di-n-propylamino)tetralin (8-OH DPAT) was found in rats 
      treated two weeks previously with a single dose of MDMA (2.0 or 20.0 mg/kg, sc). 
      These results suggest that neurochemical changes produced by MDMA are associated 
      with functional alterations as manifested by abnormal 5-HT receptor-coupled 
      neuroendocrine responses.
FAU - Poland, R E
AU  - Poland RE
AD  - Department of Psychiatry, Harbor-UCLA Medical Center, Torrance 90509.
LA  - eng
GR  - MH 00534/MH/NIMH NIH HHS/United States
GR  - S07 RR05551/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Neuropharmacology
JT  - Neuropharmacology
JID - 0236217
RN  - 0 (Serotonin Antagonists)
RN  - 0 (Tetrahydronaphthalenes)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - 78950-78-4 (8-Hydroxy-2-(di-n-propylamino)tetralin)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - 9002-62-4 (Prolactin)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/*analogs & derivatives/pharmacology
MH  - 8-Hydroxy-2-(di-n-propylamino)tetralin
MH  - Adrenocorticotropic Hormone/blood/*metabolism
MH  - Animals
MH  - Drug Interactions
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Prolactin/blood/*metabolism
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Reference Values
MH  - Serotonin Antagonists/*pharmacology
MH  - Tetrahydronaphthalenes/*pharmacology
EDAT- 1990/11/01 00:00
MHDA- 1990/11/01 00:01
CRDT- 1990/11/01 00:00
PHST- 1990/11/01 00:00 [pubmed]
PHST- 1990/11/01 00:01 [medline]
PHST- 1990/11/01 00:00 [entrez]
AID - 10.1016/0028-3908(90)90120-g [doi]
PST - ppublish
SO  - Neuropharmacology. 1990 Nov;29(11):1099-101. doi: 10.1016/0028-3908(90)90120-g.