PMID- 19823729 OWN - NLM STAT- MEDLINE DCOM- 20100224 LR - 20091013 IS - 1473-0197 (Print) IS - 1473-0189 (Linking) VI - 9 IP - 21 DP - 2009 Nov 7 TI - A simple sheath-flow microfluidic device for micro/nanomanufacturing: fabrication of hydrodynamically shaped polymer fibers. PG - 3126-30 LID - 10.1039/b910581f [doi] AB - A simple sheath flow microfluidic device is used to fabricate polymer micro/nanofibers that have precisely controlled shapes and sizes. Poly(methylmethacrylate) (PMMA) was used as the model polymer for these experiments. The sheath-flow device uses straight diagonal and chevron-shaped grooves integrated in the top and bottom walls of the flow channel to move sheath fluid completely around the polymer stream. Portions of the sheath stream are deflected in such a way as to define the cross-sectional shape of the polymer core. The flow-rate ratio between the sheath and core solution determines the fiber diameter. Round PMMA fibers with a diameter as small as 300 nm and flattened fibers with a submicron thickness are demonstrated. FAU - Thangawng, Abel L AU - Thangawng AL AD - Center for Bio/Molecular Science and Engineering, Naval Research Laboratory, Washington, DC 20375-5348, USA. FAU - Howell, Peter B Jr AU - Howell PB Jr FAU - Richards, Jeffrey J AU - Richards JJ FAU - Erickson, Jeffrey S AU - Erickson JS FAU - Ligler, Frances S AU - Ligler FS LA - eng PT - Journal Article PT - Research Support, U.S. Gov't, Non-P.H.S. DEP - 20090821 PL - England TA - Lab Chip JT - Lab on a chip JID - 101128948 RN - 9011-14-7 (Polymethyl Methacrylate) SB - IM MH - Equipment Design MH - Microfluidic Analytical Techniques/*methods MH - Microscopy, Electron, Scanning MH - Nanofibers/*chemistry MH - Polymethyl Methacrylate/*chemistry MH - Surface Properties EDAT- 2009/10/14 06:00 MHDA- 2010/02/25 06:00 CRDT- 2009/10/14 06:00 PHST- 2009/10/14 06:00 [entrez] PHST- 2009/10/14 06:00 [pubmed] PHST- 2010/02/25 06:00 [medline] AID - 10.1039/b910581f [doi] PST - ppublish SO - Lab Chip. 2009 Nov 7;9(21):3126-30. doi: 10.1039/b910581f. Epub 2009 Aug 21.