PMID- 19824774
OWN - NLM
STAT- MEDLINE
DCOM- 20091117
LR  - 20211020
IS  - 1939-0084 (Electronic)
IS  - 0735-7044 (Print)
IS  - 0735-7044 (Linking)
VI  - 123
IP  - 5
DP  - 2009 Oct
TI  - MDMA pretreatment leads to mild chronic unpredictable stress-induced impairments 
      in spatial learning.
PG  - 1076-84
LID - 10.1037/a0016716 [doi]
AB  - 3,4-Methylenedioxymethamphetamine (MDMA) is a drug of abuse worldwide and a 
      selective serotonin (5-HT) neurotoxin. An important factor in the risk of drug 
      abuse and relapse is stress. Although multiple parallels exist between MDMA abuse 
      and stress, including effects on 5-HTergic neurotransmission, few studies have 
      investigated the consequences of combined exposure to MDMA and chronic stress. 
      Therefore, rats were pretreated with MDMA and exposed 7 days later to 10 days of 
      mild chronic unpredictable stress (CUS). MDMA pretreatment was hypothesized to 
      enhance the effects of CUS leading to enhanced 5-HT transporter (SERT) depletion 
      in the hippocampus and increased anxiety and cognitive impairment. Whereas MDMA 
      alone increased anxiety-like behavior on the elevated plus maze, CUS alone or in 
      combination with MDMA pretreatment did not increase anxiety-like behavior. In 
      contrast, MDMA pretreatment led to CUS-induced learning impairment in the Morris 
      water maze but not an enhanced depletion of hippocampal SERT protein. These 
      results show that prior exposure to MDMA leads to stress-induced impairments in 
      learning behavior that is not otherwise observed with stress alone and appear 
      unrelated to an enhanced depletion of SERT.
FAU - Cunningham, Jacobi I
AU  - Cunningham JI
AD  - Laboratory of Neurochemistry, Department of Pharmacology, Boston University 
      School of Medicine, Boston, USA.
FAU - Raudensky, Jamie
AU  - Raudensky J
FAU - Tonkiss, John
AU  - Tonkiss J
FAU - Yamamoto, Bryan K
AU  - Yamamoto BK
LA  - eng
GR  - R01 DA016866/DA/NIDA NIH HHS/United States
GR  - R01 DA016866-01/DA/NIDA NIH HHS/United States
GR  - DA 016886/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Behav Neurosci
JT  - Behavioral neuroscience
JID - 8302411
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
RN  - 333DO1RDJY (Serotonin)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Blotting, Western
MH  - Exploratory Behavior/*drug effects
MH  - Hippocampus/drug effects/metabolism/physiopathology
MH  - Injections, Intraperitoneal
MH  - Male
MH  - Maze Learning/*drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*administration & dosage
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Serotonin/metabolism
MH  - Serotonin Plasma Membrane Transport Proteins/metabolism
MH  - *Stress, Physiological
MH  - Stress, Psychological/*physiopathology
PMC - PMC2786777
MID - NIHMS157207
EDAT- 2009/10/15 06:00
MHDA- 2009/11/18 06:00
PMCR- 2010/10/01
CRDT- 2009/10/15 06:00
PHST- 2009/10/15 06:00 [entrez]
PHST- 2009/10/15 06:00 [pubmed]
PHST- 2009/11/18 06:00 [medline]
PHST- 2010/10/01 00:00 [pmc-release]
AID - 2009-18253-009 [pii]
AID - 10.1037/a0016716 [doi]
PST - ppublish
SO  - Behav Neurosci. 2009 Oct;123(5):1076-84. doi: 10.1037/a0016716.