PMID- 19824775 OWN - NLM STAT- MEDLINE DCOM- 20091117 LR - 20091014 IS - 1939-0084 (Electronic) IS - 0735-7044 (Linking) VI - 123 IP - 5 DP - 2009 Oct TI - Discriminative conditioning with different CS-US intervals produces temporally differentiated conditioned responses in the two eyes of the rabbit (Oryctolagus cuniculus). PG - 1085-94 LID - 10.1037/a0016643 [doi] AB - The conditioned eyeblink response (CR) in rabbits is lateralized to the eye targeted by the unconditioned stimulus (US). However, a contralateral component has been reported during concurrent discriminative conditioning of the two eyes. The authors investigated CRs produced by both eyes during conditioning with 2 different interstimulus intervals (ISIs) in which a short conditioned stimulus (CS) was paired with a US to the left eye and a long CS was paired with a US to the right eye. Whether the 2 CSs were more or less similar (or identical), the short CS produced short-latency CRs in the left eye, whereas the long CS produced long-latency CRs in the right eye. The contralateral responses to a CS trained at one ISI were separable into temporal corollaries of the ipsilateral response (suggesting a bilaterality of the CR) versus those to a CS trained at another ISI (indicating generalization between the CSs). The results indicate that the neuronal substrates subserving CRs of the two eyes involve not only a dominant lateralization but also some avenue of bilaterality. FAU - Lee, Taekwan AU - Lee T AD - Department of Psychology, Yale University, USA. taekwan.lee@gmail.com FAU - Kim, Jeansok J AU - Kim JJ FAU - Wagner, Allan R AU - Wagner AR LA - eng PT - Journal Article PL - United States TA - Behav Neurosci JT - Behavioral neuroscience JID - 8302411 SB - IM MH - Acoustic Stimulation MH - Analysis of Variance MH - Animals MH - Auditory Perception MH - Blinking/*physiology MH - Conditioning, Eyelid/*physiology MH - Electric Stimulation MH - Functional Laterality/*physiology MH - Male MH - Rabbits MH - Time Factors EDAT- 2009/10/15 06:00 MHDA- 2009/11/18 06:00 CRDT- 2009/10/15 06:00 PHST- 2009/10/15 06:00 [entrez] PHST- 2009/10/15 06:00 [pubmed] PHST- 2009/11/18 06:00 [medline] AID - 2009-18253-010 [pii] AID - 10.1037/a0016643 [doi] PST - ppublish SO - Behav Neurosci. 2009 Oct;123(5):1085-94. doi: 10.1037/a0016643.