PMID- 19825913
OWN - NLM
STAT- MEDLINE
DCOM- 20110104
LR  - 20100820
IS  - 1938-2723 (Electronic)
IS  - 1076-0296 (Linking)
VI  - 16
IP  - 5
DP  - 2010 Oct
TI  - Hyperhomocysteinemia and C677T MTHFR genotype in patients with retinal vein 
      thrombosis.
PG  - 549-53
LID - 10.1177/1076029609348644 [doi]
AB  - INTRODUCTION: Elevated homocysteine (Hcy) is associated with the risk of deep 
      vein thrombosis, pulmonary embolism, ischemic heart disease, and stroke. Several 
      studies have suggested that hyperhomocysteinemia (HHcy) may predispose to retinal 
      vein thrombosis (RVT) development. The aim of this study is to investigate the 
      relationship between Hcy, C677T methylenetetrahydrofolate reductase (MTHFR) 
      genotype, and RVT in patients compared with controls. MATERIALS AND METHODS: We 
      evaluated the Hcy plasma level of 3114 consecutive participants in 2 Italian 
      centers during a 2-year period. Hyperhomocysteinemia was found in 99 patients and 
      136 healthy participants. Of the 99 patients, 20 had RVT with a high prevalence 
      of HHcy in the RVT subgroup (20.2%). This result suggested a possible 
      relationship between HHcy and RVT development. We investigated 105 consecutive 
      patients with recent diagnosis of RVT, and we compared them with 226 healthy 
      controls to evaluate whether HHcy may be a risk factor for RVT. RESULTS: the 
      prevalence of HHcy was higher in patients compared with controls (34.3% vs 14.2%; 
      P < .001). The MTHFR C677T genotype was found in 69 of 105 (65.7%) patients with 
      RVT (heterozygosity: 40 of 105 and homozygosity: 29 of 105). The control group 
      showed the presence of MTHFR C677T genotype in 169 of 226 participants (74.8%; 
      heterozygosity: 100 of 226 and homozygosity: 69 of 226) without difference 
      between the 2 groups (P = .08). CONCLUSION: our study suggests that HHcy is a 
      possible risk factor for RVT development, while no association was found between 
      RVT and the C677T MTHFR genotype.
FAU - Sottilotta, Gianluca
AU  - Sottilotta G
AD  - Hemophilia Centre, Hemostasis and Thrombosis Service, Azienda Ospedaliera 
      "Bianchi-Melacrino-Morelli", Reggio Calabria, Italy. 
      gianluca.sottilotta@virgilio.it
FAU - Siboni, Simona Maria
AU  - Siboni SM
FAU - Latella, Caterina
AU  - Latella C
FAU - Oriana, Vincenzo
AU  - Oriana V
FAU - Romeo, Ermelinda
AU  - Romeo E
FAU - Santoro, Rita
AU  - Santoro R
FAU - Consonni, Dario
AU  - Consonni D
FAU - Trapani Lombardo, Vincenzo
AU  - Trapani Lombardo V
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20091013
PL  - United States
TA  - Clin Appl Thromb Hemost
JT  - Clinical and applied thrombosis/hemostasis : official journal of the 
      International Academy of Clinical and Applied Thrombosis/Hemostasis
JID - 9508125
RN  - EC 1.5.1.20 (Methylenetetrahydrofolate Reductase (NADPH2))
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Case-Control Studies
MH  - Cohort Studies
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Hyperhomocysteinemia/*blood/*genetics
MH  - Male
MH  - Methylenetetrahydrofolate Reductase (NADPH2)/*genetics
MH  - Middle Aged
MH  - Polymorphism, Genetic
MH  - Retinal Vein Occlusion/*blood/*genetics
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Young Adult
EDAT- 2009/10/15 06:00
MHDA- 2011/01/05 06:00
CRDT- 2009/10/15 06:00
PHST- 2009/10/15 06:00 [entrez]
PHST- 2009/10/15 06:00 [pubmed]
PHST- 2011/01/05 06:00 [medline]
AID - 1076029609348644 [pii]
AID - 10.1177/1076029609348644 [doi]
PST - ppublish
SO  - Clin Appl Thromb Hemost. 2010 Oct;16(5):549-53. doi: 10.1177/1076029609348644. 
      Epub 2009 Oct 13.