PMID- 19826190
OWN - NLM
STAT- MEDLINE
DCOM- 20100330
LR  - 20191210
IS  - 1899-1505 (Electronic)
IS  - 0867-5910 (Linking)
VI  - 60
IP  - 3
DP  - 2009 Sep
TI  - The effects of fatty acid amide hydrolase inhibitors on maintenance of cocaine 
      and food self-administration and on reinstatement of cocaine-seeking and 
      food-taking behavior in rats.
PG  - 119-25
AB  - Some empirical evidence suggests that the endocannabinoids (eCB) (e.g. 
      anandamide) may play an important role in cocaine addiction. The eCB act as a 
      retrograde messengers activating CB receptors at the presynaptic membrane and are 
      degraded by enzymatic actions of fatty acid amide hydrolase (FAAH). The present 
      study aimed to examine the effect of the FAAH inhibitors, phenylmethylsulphonyl 
      fluoride (PMSF; i.p.) or cyclohexylcarbamic acid 3-carbamoyl biphenyl-3-yl ester 
      (URB597; i.p.) on the cocaine- or food-maintained self-administration as well as 
      on the cocaine-seeking or food-taking behaviors in rats. Male Wistar rats were 
      implanted with a catheter (iv.) and trained to self-administer cocaine (0.5 
      mg/kg/infusion) on a fixed ratio 5 schedule of reinforcement with a conditioned 
      stimulus (tone+light). After self-administration stabilized, 
      extinction/reinstatement procedures were carried out during which the rats were 
      tested for the response reinstatement induced by cocaine (10 mg/kg, ip) or a cue 
      (light+tone). The food (sweetened milk) self-administration and 
      extinction/reinstatement procedures were conducted in a manner resembling cocaine 
      self-administration. Neither PMSF (30-120 mg/kg) nor URB597 (0.1-3 mg/kg) 
      affected cocaine self-administration. PMSF, 60 mg/kg, significantly reduced 
      cocaine-induced reinstatement and at 120 mg/kg (combined with the challenge dose 
      of cocaine) it evoked behavioral disruption. PMSF (60-120 mg/kg) dose-dependently 
      inhibited cue-induced reinstatement. URB597 (1-3 mg/kg) attenuated both cocaine- 
      and cue-induced drug-seeking behaviors. PMSF (60 mg/kg) decreased food 
      self-administration. Toward reinstatement of food-taking behavior PMSF (60-120 
      mg/kg) and URB597 (3 mg/kg) showed inhibitory effects. Our results indicate that 
      FAAH inhibitors could be potent modulators of motivational and conditioned 
      aspects of goal-directed behaviors with less prominent effects on consumatory 
      behaviors.
FAU - Adamczyk, P
AU  - Adamczyk P
AD  - Department of Pharmacology, Institute of Pharmacology, Polish Academy of 
      Sciences, Cracow, Poland.
FAU - McCreary, A C
AU  - McCreary AC
FAU - Przegalinski, E
AU  - Przegalinski E
FAU - Mierzejewski, P
AU  - Mierzejewski P
FAU - Bienkowski, P
AU  - Bienkowski P
FAU - Filip, M
AU  - Filip M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Poland
TA  - J Physiol Pharmacol
JT  - Journal of physiology and pharmacology : an official journal of the Polish 
      Physiological Society
JID - 9114501
RN  - 0 (Benzamides)
RN  - 0 (Carbamates)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester)
RN  - 57KD15003I (Phenylmethylsulfonyl Fluoride)
RN  - EC 3.5.- (Amidohydrolases)
RN  - EC 3.5.1.- (fatty-acid amide hydrolase)
RN  - I5Y540LHVR (Cocaine)
SB  - IM
MH  - Amidohydrolases/*antagonists & inhibitors
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Benzamides/administration & dosage/pharmacology
MH  - Carbamates/administration & dosage/pharmacology
MH  - Cocaine/*administration & dosage
MH  - Cocaine-Related Disorders/enzymology/metabolism/*psychology
MH  - Consummatory Behavior/drug effects
MH  - Dose-Response Relationship, Drug
MH  - Eating/*drug effects
MH  - Enzyme Inhibitors/administration & dosage/*pharmacology
MH  - Extinction, Psychological/drug effects
MH  - Feeding Behavior/drug effects
MH  - Injections, Intraperitoneal
MH  - Male
MH  - Phenylmethylsulfonyl Fluoride/administration & dosage/pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - *Reinforcement, Psychology
MH  - Self Administration
EDAT- 2009/10/15 06:00
MHDA- 2010/03/31 06:00
CRDT- 2009/10/15 06:00
PHST- 2008/09/22 00:00 [received]
PHST- 2009/07/15 00:00 [accepted]
PHST- 2009/10/15 06:00 [entrez]
PHST- 2009/10/15 06:00 [pubmed]
PHST- 2010/03/31 06:00 [medline]
PST - ppublish
SO  - J Physiol Pharmacol. 2009 Sep;60(3):119-25.