PMID- 1982692
OWN - NLM
STAT- MEDLINE
DCOM- 19910617
LR  - 20190712
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 37
IP  - 4
DP  - 1990 Dec
TI  - Methylenedioxymethamphetamine's capacity to establish place preferences and 
      modify intake of an alcoholic beverage.
PG  - 633-8
AB  - Doses of 0.2, 2.0, 6.3 and 20.0 mg/kg 3,4-methylenedioxymethamphetamine (MDMA), a 
      putative neurotoxin at serotonergic neurons and a recreational drug, were 
      assessed using Sprague-Dawley rats in the conditioned place preference (CPP) 
      test. Also, the drug's effects on intake of a sweetened ethanol solution (ES) was 
      assessed. The CP testing involved multiple administrations of MDMA with frequent 
      periodic testing (weekly for 4 weeks) of MDMA's effects. Doses of 2.0 and 6.3 
      mg/kg produced positive CPPs with every test. MDMA also affected rats' gain in 
      body weight across the 4 weeks of dosing. The 2.0 mg/kg reliably incremented gain 
      in body weight, while the 20.0 mg/kg dose reliably attenuated it. In the drinking 
      experiment, water-deprived rats (22 h/day) were given daily opportunities to 
      drink either tap water or a sweetened ES. When stable intakes were achieved, 
      MDMA's effects were assessed across repeated daily administrations (12 days) and 
      subsequently (16 days). MDMA, dose-relatedly, decreased intake of both ES and 
      water with the highest dose leading to marked loss in body weight. Intakes of 
      fluids were not modified markedly subsequent to dosing. In summary, MDMA is an 
      agent that produces a positive CPP (providing further evidence for MDMA's abuse 
      liability), produces changes in weight gain and nonselectively reduces fluid 
      intake among fluid-deprived rats.
FAU - Bilsky, E J
AU  - Bilsky EJ
AD  - Department of Psychology, Rensselaer Polytechnic Institute, Troy, NY 12180-3590.
FAU - Hui, Y Z
AU  - Hui YZ
FAU - Hubbell, C L
AU  - Hubbell CL
FAU - Reid, L D
AU  - Reid LD
LA  - eng
GR  - DA 04440/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/*analogs & derivatives/pharmacology
MH  - *Alcohol Drinking
MH  - Animals
MH  - Body Weight/drug effects
MH  - Conditioning, Operant/*drug effects
MH  - Dose-Response Relationship, Drug
MH  - Drinking/drug effects
MH  - Drug Tolerance
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Rats
MH  - Rats, Inbred Strains
EDAT- 1990/12/01 00:00
MHDA- 1990/12/01 00:01
CRDT- 1990/12/01 00:00
PHST- 1990/12/01 00:00 [pubmed]
PHST- 1990/12/01 00:01 [medline]
PHST- 1990/12/01 00:00 [entrez]
AID - 0091-3057(90)90538-S [pii]
AID - 10.1016/0091-3057(90)90538-s [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 1990 Dec;37(4):633-8. doi: 10.1016/0091-3057(90)90538-s.