PMID- 19827503
OWN - NLM
STAT- MEDLINE
DCOM- 20100826
LR  - 20191111
IS  - 1056-6716 (Print)
IS  - 1056-6716 (Linking)
VI  - 18
IP  - 3
DP  - 2009 Aug
TI  - Electroacupuncture-enhanced differentiation of bone marrow stromal cells into 
      neuronal cells.
PG  - 398-406
AB  - CONTEXT: Bone marrow stromal cells (BMSCs) can be differentiated into neuronal 
      cells and are used to treat spinal cord injury (SCI). OBJECTIVE: This study 
      investigated whether electroacupuncture enhances BMSC's effects on SCI in rats. 
      DESIGN: The effects of transplantation of phosphate-buffered saline or BMSC, 
      electroacupuncture, and a combination of BMSC transplantation and 
      electroacupuncture on SCI were evaluated using a combined behavioral score (CBS). 
      Expressions of neuronal marker neuron-specific enolase (NSE) and 
      gliocyte-specific marker glial fibrillary acidic protein (GFAP) of transplanted 
      BMSC were detected using immunohistochemistry to assess the effect of 
      electroacupuncture on differentiation of BMSC into neuronal cells. RESULTS: The 
      combination of BMSC transplantation and electroacupuncture significantly 
      alleviated CBS in rats with SCI compared with the separate treatment of BMSC or 
      electroacupuncture. In addition, electroacupuncture increased the NSE- and 
      GFAP-positive transplanted BMSCs in spinal cord. CONCLUSION: Combined treatment 
      showed a better effect, and the mechanisms may be partially caused by enhanced 
      differentiation of BMSC into neuronal cells. Future studies are needed to confirm 
      this.
FAU - Sun, Zhongren
AU  - Sun Z
AD  - Institute of Acupuncture and Moxibustion, Second Affiliated Hospital of 
      Heilongjiang University of Traditional Medicine, Harbin 150001, People's Republic 
      of China (PRC).
FAU - Li, Xiaoning
AU  - Li X
FAU - Su, Zhiqiang
AU  - Su Z
FAU - Zhao, Ying
AU  - Zhao Y
FAU - Zhang, Li
AU  - Zhang L
FAU - Wu, Mingyuan
AU  - Wu M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Sport Rehabil
JT  - Journal of sport rehabilitation
JID - 9206500
RN  - 0 (Biomarkers)
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - EC 4.2.1.11 (Phosphopyruvate Hydratase)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Biomarkers
MH  - Bone Marrow Transplantation
MH  - Cell Differentiation/*physiology
MH  - Disease Models, Animal
MH  - *Electroacupuncture
MH  - Glial Fibrillary Acidic Protein/metabolism
MH  - Male
MH  - Neurons/*cytology
MH  - Phosphopyruvate Hydratase/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Spinal Cord Injuries/metabolism/*therapy
MH  - Stromal Cells/cytology/*physiology/transplantation
EDAT- 2009/10/16 06:00
MHDA- 2010/08/27 06:00
CRDT- 2009/10/16 06:00
PHST- 2009/10/16 06:00 [entrez]
PHST- 2009/10/16 06:00 [pubmed]
PHST- 2010/08/27 06:00 [medline]
AID - 10.1123/jsr.18.3.398 [doi]
PST - ppublish
SO  - J Sport Rehabil. 2009 Aug;18(3):398-406. doi: 10.1123/jsr.18.3.398.