PMID- 1982864
OWN - NLM
STAT- MEDLINE
DCOM- 19910718
LR  - 20190813
IS  - 0300-0664 (Print)
IS  - 0300-0664 (Linking)
VI  - 33
IP  - 6
DP  - 1990 Dec
TI  - Screening for multiple endocrine neoplasia type 1 in patients with recognized 
      pituitary adenoma.
PG  - 771-5
AB  - A total of 79 consecutive patients with pituitary tumours were screened for 
      multiple endocrine neoplasia type 1 (MEN-1). The 79 patients included 21 patients 
      with acromegaly, nine with Cushing's disease, 18 with prolactinomas, three with 
      mixed pituitary adenomas (GH and PRL), and 28 patients with no detectable 
      hypersecretion of hormones. The screening consisted of: (1) a family history, (2) 
      a uniform medical history of the patient using a standard questionnaire, and (3) 
      hormonal evaluation including measurements of the serum levels of insulin, 
      gastrin, glucagon, somatostatin, vasoactive intestinal polypeptide and pancreatic 
      polypeptide. Ionized calcium and glucose concentration in serum were also 
      measured. We found no patients with the MEN-1 syndrome. In one patient, we found 
      a transient elevation of serum concentrations of pancreatic polypeptide for which 
      we have no explanation. In another patient, the serum gastrin concentration was 
      elevated secondary to achlorhydria. No other endocrine disorders were found, and 
      no patients had relatives with recognized endocrine pancreatic tumours, primary 
      hyperparathyroidism (HPT), or pituitary adenomas.
FAU - Andersen, H O
AU  - Andersen HO
AD  - Department of Surgical Gastroenterology C, Rigshopitalet, Copenhagen, Denmark.
FAU - Jorgensen, P E
AU  - Jorgensen PE
FAU - Bardram, L
AU  - Bardram L
FAU - Hilsted, L
AU  - Hilsted L
LA  - eng
PT  - Journal Article
PL  - England
TA  - Clin Endocrinol (Oxf)
JT  - Clinical endocrinology
JID - 0346653
RN  - 0 (Gastrointestinal Hormones)
RN  - 0 (Pancreatic Hormones)
RN  - 51110-01-1 (Somatostatin)
SB  - IM
MH  - *Adenoma/blood
MH  - Adult
MH  - Aged
MH  - Cohort Studies
MH  - Female
MH  - Gastrointestinal Hormones/blood
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia/*diagnosis
MH  - Pancreatic Hormones/blood
MH  - *Pituitary Neoplasms/blood
MH  - Prospective Studies
MH  - Somatostatin/blood
EDAT- 1990/12/01 00:00
MHDA- 1990/12/01 00:01
CRDT- 1990/12/01 00:00
PHST- 1990/12/01 00:00 [pubmed]
PHST- 1990/12/01 00:01 [medline]
PHST- 1990/12/01 00:00 [entrez]
AID - 10.1111/j.1365-2265.1990.tb03914.x [doi]
PST - ppublish
SO  - Clin Endocrinol (Oxf). 1990 Dec;33(6):771-5. doi: 
      10.1111/j.1365-2265.1990.tb03914.x.