PMID- 19829297
OWN - NLM
STAT- MEDLINE
DCOM- 20100730
LR  - 20100330
IS  - 1476-5543 (Electronic)
IS  - 0743-8346 (Linking)
VI  - 30
IP  - 4
DP  - 2010 Apr
TI  - Fluctuations in anti-factor Xa levels with therapeutic enoxaparin anticoagulation 
      in pregnancy.
PG  - 253-7
LID - 10.1038/jp.2009.164 [doi]
AB  - OBJECTIVE: The objective of the study was to evaluate anti-factor Xa levels with 
      therapeutic enoxaparin anticoagulation in pregnancy. STUDY DESIGN: A total of 15 
      pregnant subjects on therapeutic doses of enoxaparin (1 mg/kg +/-20% 
      subcutaneously (s.c.) twice daily (b.i.d.)) were enrolled prospectively in this 
      cross-sectional pilot project. Three blood levels for anti-factor Xa activity 
      were examined: before the enoxaparin dose (trough), 3- to 4-h later (peak) and 
      8-h later. Anti-factor Xa activity level between 0.5 and 1.2 U/ml was considered 
      therapeutic. RESULT: Mean anti-factor Xa activity levels were: trough 
      0.45+/-0.18, peak 0.9+/-0.25 and 8-h after dose 0.72+/-0.23 U/ml. All peak levels 
      were therapeutic; 20% (3/15) of the 8 h and 73% (11/15) of the trough levels were 
      sub-therapeutic. CONCLUSION: Trough and 8-h post-dose anti-factor Xa activity 
      levels were sub-therapeutic in a substantial number of patients receiving a 
      b.i.d. regimen of therapeutic enoxaparin.
FAU - Friedrich, E
AU  - Friedrich E
AD  - Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, 
      University of California, Irvine, Orange, CA 92868, USA. efriedri@uci.edu
FAU - Hameed, A B
AU  - Hameed AB
LA  - eng
SI  - ClinicalTrials.gov/NCT00319176
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091015
PL  - United States
TA  - J Perinatol
JT  - Journal of perinatology : official journal of the California Perinatal 
      Association
JID - 8501884
RN  - 0 (Enoxaparin)
RN  - 0 (Fibrinolytic Agents)
RN  - EC 3.4.21.6 (Factor Xa)
SB  - IM
MH  - Adult
MH  - Cross-Sectional Studies
MH  - Drug Administration Schedule
MH  - *Drug Monitoring
MH  - Enoxaparin/*administration & dosage/analysis
MH  - Factor Xa/*analysis
MH  - Female
MH  - Fibrinolytic Agents/*administration & dosage
MH  - Humans
MH  - Injections, Subcutaneous
MH  - Pilot Projects
MH  - Pregnancy
MH  - Pregnancy Complications, Hematologic/*drug therapy
MH  - Thrombophilia/*drug therapy
MH  - Young Adult
EDAT- 2009/10/16 06:00
MHDA- 2010/07/31 06:00
CRDT- 2009/10/16 06:00
PHST- 2009/10/16 06:00 [entrez]
PHST- 2009/10/16 06:00 [pubmed]
PHST- 2010/07/31 06:00 [medline]
AID - jp2009164 [pii]
AID - 10.1038/jp.2009.164 [doi]
PST - ppublish
SO  - J Perinatol. 2010 Apr;30(4):253-7. doi: 10.1038/jp.2009.164. Epub 2009 Oct 15.