PMID- 1983502
OWN - NLM
STAT- MEDLINE
DCOM- 19920331
LR  - 20080226
IS  - 0173-0541 (Print)
IS  - 0173-0541 (Linking)
DP  - 1990
TI  - [Pharmacologic and clinical principles for rational anti-thrombotic preventive 
      treatment with low molecular weight heparin].
PG  - 1149-55
AB  - Heparin exerts its anticoagulant function by accelerating the inhibitory effect 
      of antithrombin III. Low molecular weight heparin (LMWH), which is derived from 
      unfractionated heparin (UFH), exhibits marked anti-Xa activity and minor thrombin 
      inhibition. It has an elevated bioavailability and longer half-life as to the 
      anti-Xa clearance when compared to UFH. Platelet, endothelial and fibrinolytic 
      effects are also involved in antithrombotic action. Clinical trials have shown 
      that LMWH compared to UFH is an equivalent and even advantageous method of 
      antithrombotic prophylaxis in surgical patients and has also a minor risk of 
      bleeding.
FAU - Pindur, G
AU  - Pindur G
AD  - Abteilung fur Klinische Hamostaseologie und Transfusionsmedizin, 
      Universitatskliniken des Saarlandes, Homburg.
FAU - Kohler, M
AU  - Kohler M
FAU - Heiden, M
AU  - Heiden M
FAU - Leipnitz, C
AU  - Leipnitz C
FAU - Rupp, K H
AU  - Rupp KH
FAU - Wenzel, E
AU  - Wenzel E
LA  - ger
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Pharmakologische und klinische Grundlagen zur rationellen antithrombotischen 
      Prophylaxe mit niedermolekularem Heparin.
PL  - Germany
TA  - Langenbecks Arch Chir Suppl II Verh Dtsch Ges Chir
JT  - Langenbecks Archiv fur Chirurgie. Supplement II, Verhandlungen der Deutschen 
      Gesellschaft fur Chirurgie. Deutsche Gesellschaft fur Chirurgie. Kongress
JID - 9200455
RN  - 0 (Heparin, Low-Molecular-Weight)
SB  - IM
MH  - Blood Coagulation Tests
MH  - Dose-Response Relationship, Drug
MH  - Drug Administration Schedule
MH  - Heparin, Low-Molecular-Weight/adverse effects/*pharmacokinetics/*therapeutic use
MH  - Humans
MH  - Postoperative Complications/blood/*prevention & control
MH  - Risk Factors
MH  - Thrombosis/blood/*prevention & control
RF  - 13
EDAT- 1990/01/01 00:00
MHDA- 1990/01/01 00:01
CRDT- 1990/01/01 00:00
PHST- 1990/01/01 00:00 [pubmed]
PHST- 1990/01/01 00:01 [medline]
PHST- 1990/01/01 00:00 [entrez]
PST - ppublish
SO  - Langenbecks Arch Chir Suppl II Verh Dtsch Ges Chir. 1990:1149-55.