PMID- 19835851
OWN - NLM
STAT- MEDLINE
DCOM- 20100128
LR  - 20220321
IS  - 1872-7786 (Electronic)
IS  - 0009-2797 (Linking)
VI  - 183
IP  - 1
DP  - 2010 Jan 5
TI  - Sesamin attenuates behavioral, biochemical and histological alterations induced 
      by reversible middle cerebral artery occlusion in the rats.
PG  - 255-63
LID - 10.1016/j.cbi.2009.10.003 [doi]
AB  - Restoration of blood flow to an ischemic brain region is associated with 
      generation of reactive oxygen species (ROS) with consequent reperfusion injury. 
      ROS cause lipid peroxidation, protein oxidation, and DNA damage, all of which are 
      deleterious to cells. So diminishing the production of free radicals and 
      scavenging them may be a successful therapeutic strategy for the protection of 
      brain tissue in cerebral stroke. The present study investigated the 
      neuroprotective effect of sesamin (Sn) to reduce brain injury after middle 
      cerebral artery occlusion (MCAO). The middle cerebral artery (MCA) of adult male 
      Wistar rat was occluded for 2h and reperfused for 22h. Sesamin is the most 
      abundant lignan in sesame seed oil is a potent antioxidant. Sesamin (30 mg/kg) 
      was given orally twice, 30 min before the onset of ischemia and 12h after 
      reperfusion. The initial investigations revealed that sesamin reduced the 
      neurological deficits in terms of behavior and reduced the level of 
      thiobarbituric acid reactive species (TBARS), and protein carbonyl (PC) in the 
      different areas of the brain when compared with the MCAO group. A significantly 
      depleted level of glutathione and its dependent enzymes (glutathione peroxidase 
      [GPx] and glutathione reductase [GR]) in MCAO group were protected significantly 
      in MCAO group treated with sesamin. The present study suggests that sesamin may 
      be able to attenuate the ischemic cell death and plays a crucial role as a 
      neuroprotectant in regulating levels of reactive oxygen species in the rat brain. 
      Thus, sesamin may be a potential compound in stroke therapy.
FAU - Khan, Mohd Moshahid
AU  - Khan MM
AD  - Neurotoxicology Laboratory, Department of Medical Elementology & Toxicology (Fund 
      for the Improvement of Science and Technology sponsored by DST and Special 
      Assistance Programme sponsored by UGC), Jamia Hamdard (Hamdard University), 
      Hamdard Nagar, New Delhi-110062, India. mushahidkhn@yahoo.co.in
FAU - Ishrat, Tauheed
AU  - Ishrat T
FAU - Ahmad, Ajmal
AU  - Ahmad A
FAU - Hoda, Md Nasrul
AU  - Hoda MN
FAU - Khan, M Badruzzaman
AU  - Khan MB
FAU - Khuwaja, Gulrana
AU  - Khuwaja G
FAU - Srivastava, Pallavi
AU  - Srivastava P
FAU - Raza, Syed Shadab
AU  - Raza SS
FAU - Islam, Fakhrul
AU  - Islam F
FAU - Ahmad, Saif
AU  - Ahmad S
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Chem Biol Interact
JT  - Chemico-biological interactions
JID - 0227276
RN  - 0 (Antioxidants)
RN  - 0 (Dioxoles)
RN  - 0 (Lignans)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Reactive Oxygen Species)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.8.1.7 (Glutathione Reductase)
RN  - EC 7.2.2.13 (Sodium-Potassium-Exchanging ATPase)
RN  - GAN16C9B8O (Glutathione)
RN  - S7946O4P76 (sesamin)
SB  - IM
MH  - Animals
MH  - Antioxidants/*pharmacology
MH  - Behavior, Animal/drug effects
MH  - Dioxoles/*pharmacology
MH  - Glutathione/metabolism
MH  - Glutathione Peroxidase/metabolism
MH  - Glutathione Reductase/metabolism
MH  - Infarction, Middle Cerebral Artery/drug therapy/*metabolism/pathology
MH  - Lignans/*pharmacology
MH  - Male
MH  - Motor Activity/drug effects
MH  - Neuroprotective Agents/*pharmacology
MH  - Protein Carbonylation
MH  - Rats
MH  - Rats, Wistar
MH  - Reactive Oxygen Species/metabolism
MH  - Sodium-Potassium-Exchanging ATPase/metabolism
MH  - Thiobarbituric Acid Reactive Substances/metabolism
EDAT- 2009/10/20 06:00
MHDA- 2010/01/29 06:00
CRDT- 2009/10/20 06:00
PHST- 2009/07/05 00:00 [received]
PHST- 2009/10/01 00:00 [revised]
PHST- 2009/10/07 00:00 [accepted]
PHST- 2009/10/20 06:00 [entrez]
PHST- 2009/10/20 06:00 [pubmed]
PHST- 2010/01/29 06:00 [medline]
AID - S0009-2797(09)00432-3 [pii]
AID - 10.1016/j.cbi.2009.10.003 [doi]
PST - ppublish
SO  - Chem Biol Interact. 2010 Jan 5;183(1):255-63. doi: 10.1016/j.cbi.2009.10.003.