PMID- 19836158
OWN - NLM
STAT- MEDLINE
DCOM- 20100727
LR  - 20191210
IS  - 1879-355X (Electronic)
IS  - 0360-3016 (Linking)
VI  - 77
IP  - 4
DP  - 2010 Jul 15
TI  - Interobserver variation of clinical target volume delineation in gastric cancer.
PG  - 1166-70
LID - 10.1016/j.ijrobp.2009.06.023 [doi]
AB  - PURPOSE: To evaluate interobserver variability in clinical target volume (CTV) 
      delineation in gastric cancer performed with the help of a delineation guide. 
      PATIENTS AND METHODS: Ten radiotherapy centers that participate in the CRITICS 
      Phase III trial were provided with a delineation atlas, preoperative CT scans, a 
      postoperative planning CT scan, and clinical information for a gastric cancer 
      case and were asked to construct a CTV and create a dosimetric plan according to 
      departmental policy. RESULTS: The volumes of the CTVs and planning target volumes 
      (PTVs) differed greatly, with a mean (SD) CTV volume of 392 (176) cm(3) (range, 
      240-821 cm(3)) and PTV volume of 915 (312) cm(3) (range, 634-1677 cm(3)). The 
      overlapping volume was 376 cm(3) for the CTV and 890 cm(3) for the PTV. The 
      greatest differences in the CTV were seen at the cranial and caudal parts. After 
      planning, dose coverage of the overlapping PTV volume showed less variability 
      than the CTV. CONCLUSION: In this series of 10 plans, variability of the CTV in 
      postoperative chemoradiotherapy for gastric cancer is large. Strict and clear 
      delineation guidelines should be provided, especially in Phase III multicenter 
      studies. Adaptations of these guidelines should be evaluated in clinical studies.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Jansen, Edwin P M
AU  - Jansen EP
AD  - Department of Radiotherapy, The Netherlands Cancer Institute/Antoni van 
      Leeuwenhoek Hospital, Amsterdam, The Netherlands. epm.jansen@nki.nl
FAU - Nijkamp, Jasper
AU  - Nijkamp J
FAU - Gubanski, Michael
AU  - Gubanski M
FAU - Lind, Pehr A R M
AU  - Lind PA
FAU - Verheij, Marcel
AU  - Verheij M
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20091014
PL  - United States
TA  - Int J Radiat Oncol Biol Phys
JT  - International journal of radiation oncology, biology, physics
JID - 7603616
SB  - IM
MH  - *Adenocarcinoma/diagnostic imaging/pathology/radiotherapy/surgery
MH  - Cancer Care Facilities
MH  - Female
MH  - Humans
MH  - Kidney/radiation effects
MH  - *Medical Illustration
MH  - Middle Aged
MH  - Netherlands
MH  - Observer Variation
MH  - *Stomach Neoplasms/diagnostic imaging/pathology/radiotherapy/surgery
MH  - Sweden
MH  - Tomography, X-Ray Computed
MH  - *Tumor Burden
EDAT- 2009/10/20 06:00
MHDA- 2010/07/28 06:00
CRDT- 2009/10/20 06:00
PHST- 2009/02/16 00:00 [received]
PHST- 2009/06/08 00:00 [revised]
PHST- 2009/06/08 00:00 [accepted]
PHST- 2009/10/20 06:00 [entrez]
PHST- 2009/10/20 06:00 [pubmed]
PHST- 2010/07/28 06:00 [medline]
AID - S0360-3016(09)00931-6 [pii]
AID - 10.1016/j.ijrobp.2009.06.023 [doi]
PST - ppublish
SO  - Int J Radiat Oncol Biol Phys. 2010 Jul 15;77(4):1166-70. doi: 
      10.1016/j.ijrobp.2009.06.023. Epub 2009 Oct 14.