PMID- 19836301
OWN - NLM
STAT- MEDLINE
DCOM- 20100223
LR  - 20220318
IS  - 1873-5967 (Electronic)
IS  - 1386-6532 (Linking)
VI  - 46 Suppl 4
DP  - 2009 Dec
TI  - DECIBEL study: Congenital cytomegalovirus infection in young children with 
      permanent bilateral hearing impairment in the Netherlands.
PG  - S27-31
LID - 10.1016/j.jcv.2009.09.007 [doi]
AB  - BACKGROUND: A significant number of asymptomatic newborns infected with 
      congenital cytomegalovirus (CMV) will present with permanent childhood hearing 
      impairment (PCHI) during early childhood. OBJECTIVES: To investigate the role of 
      congenital CMV infection in causing PCHI in the Netherlands, and assess the 
      efficacy of two different hearing screening strategies and the developmental 
      outcome following each strategy. STUDY DESIGN: We included 192 children with PCHI 
      at the age of 3-5 years, who were offered hearing screening in their first year 
      of life. Dried blood spots from 171 children were available for CMV detection 
      using real-time PCR. The results of eight previously tested samples were also 
      available. Clinical baseline characteristics were collected from medical records 
      and the Child Development Inventory was used to investigate the developmental 
      outcome. RESULTS: The rate of congenital CMV among the 179 children was 8% 
      (14/179) and 23% (9/39) among children with profound PCHI. Two of eight 
      CMV-positive children with PCHI at the age of 3-5 years had passed the newborn 
      hearing screening (NHS) test. Developmental outcome measures showed a 
      significantly greater delay in language comprehension in children with both PCHI 
      and congenital CMV infection (the largest in symptomatic children) than in the 
      children with PCHI without congenital CMV infection. CONCLUSIONS: Congenital CMV 
      infection is important in the etiology of PCHI. Universal NHS is not a guarantee 
      of normal hearing and development in childhood for children with congenital CMV 
      infection. This is a problem which might be solved by universal congenital CMV 
      screening.
FAU - Korver, A M H
AU  - Korver AM
AD  - Willem-Alexander Children and Youth Center, Sub-department of Social Pediatrics, 
      Leiden University Medical Center, The Netherlands. a.m.h.korver@lumc.nl
FAU - de Vries, J J C
AU  - de Vries JJ
FAU - Konings, S
AU  - Konings S
FAU - de Jong, J W
AU  - de Jong JW
FAU - Dekker, F W
AU  - Dekker FW
FAU - Vossen, A C T M
AU  - Vossen AC
FAU - Frijns, J H M
AU  - Frijns JH
FAU - Oudesluys-Murphy, A M
AU  - Oudesluys-Murphy AM
CN  - DECIBEL collaborative study group
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Clin Virol
JT  - Journal of clinical virology : the official publication of the Pan American 
      Society for Clinical Virology
JID - 9815671
SB  - IM
MH  - Child, Preschool
MH  - Cytomegalovirus Infections/*complications/congenital/*epidemiology/virology
MH  - Developmental Disabilities/epidemiology/virology
MH  - Female
MH  - Hearing Loss, Bilateral/*epidemiology/*virology
MH  - Humans
MH  - Male
MH  - Netherlands/epidemiology
FIR - Oudesluys-Murphy, A M
IR  - Oudesluys-Murphy AM
FIR - Korver, A M H
IR  - Korver AM
FIR - Frijns, J H M
IR  - Frijns JH
FIR - Wever, C C
IR  - Wever CC
FIR - Konings, S
IR  - Konings S
FIR - Beers, M
IR  - Beers M
FIR - Soede, W
IR  - Soede W
FIR - Dekker, F W
IR  - Dekker FW
FIR - Vossen, A C T M
IR  - Vossen AC
FIR - De Vries, J J C
IR  - De Vries JJ
FIR - Kant, S G
IR  - Kant SG
FIR - Van den Akker-van Marle, M E
IR  - Van den Akker-van Marle ME
FIR - Rieffe, C
IR  - Rieffe C
FIR - Ens-Dokkum, M H
IR  - Ens-Dokkum MH
FIR - Van Straaten, H L M
IR  - Van Straaten HL
FIR - Meuwese-Jongejeugd, J
IR  - Meuwese-Jongejeugd J
FIR - Elvers, B
IR  - Elvers B
FIR - Loeber, G
IR  - Loeber G
FIR - Mare, M J
IR  - Mare MJ
FIR - Van Zanten, G A
IR  - Van Zanten GA
FIR - Goedegebure, A
IR  - Goedegebure A
FIR - Coster, F
IR  - Coster F
FIR - De Leeuw, M
IR  - De Leeuw M
FIR - Dijkhuizen, J
IR  - Dijkhuizen J
FIR - Scharloo, M
IR  - Scharloo M
FIR - Hoeben, D
IR  - Hoeben D
FIR - Rijpma, G
IR  - Rijpma G
FIR - Graef, W
IR  - Graef W
FIR - Linschoten, D
IR  - Linschoten D
FIR - Kuijper, J
IR  - Kuijper J
FIR - Hof, N J
IR  - Hof NJ
FIR - Pans, D
IR  - Pans D
FIR - Jorritsma, F
IR  - Jorritsma F
FIR - Van Beurden, M
IR  - Van Beurden M
FIR - Ter Huurne, C T
IR  - Ter Huurne CT
FIR - Brienesse, P
IR  - Brienesse P
FIR - Koldewijn, G J
IR  - Koldewijn GJ
FIR - Letourneur, K G
IR  - Letourneur KG
FIR - Seekles, L
IR  - Seekles L
FIR - De Jong, J W
IR  - De Jong JW
FIR - Thijssen, A
IR  - Thijssen A
FIR - Lievense, A
IR  - Lievense A
FIR - Van Egdom-van der Wind, M
IR  - Van Egdom-van der Wind M
FIR - Theunissen, S C P M
IR  - Theunissen SC
FIR - Mooij, S
IR  - Mooij S
EDAT- 2009/10/20 06:00
MHDA- 2010/02/24 06:00
CRDT- 2009/10/20 06:00
PHST- 2009/03/28 00:00 [received]
PHST- 2009/08/13 00:00 [accepted]
PHST- 2009/10/20 06:00 [entrez]
PHST- 2009/10/20 06:00 [pubmed]
PHST- 2010/02/24 06:00 [medline]
AID - S1386-6532(09)00423-5 [pii]
AID - 10.1016/j.jcv.2009.09.007 [doi]
PST - ppublish
SO  - J Clin Virol. 2009 Dec;46 Suppl 4:S27-31. doi: 10.1016/j.jcv.2009.09.007.