PMID- 19837298
OWN - NLM
STAT- MEDLINE
DCOM- 20091103
LR  - 20220408
IS  - 1531-5053 (Electronic)
IS  - 0278-2391 (Linking)
VI  - 67
IP  - 11
DP  - 2009 Nov
TI  - Effect of a syndromic diagnosis on mandibular size and sagittal position in Robin 
      sequence.
PG  - 2323-31
LID - 10.1016/j.joms.2009.06.010 [doi]
AB  - PURPOSE: Despite its pathogenic heterogeneity, it is often assumed that the small 
      mandible in a neonate with Robin sequence will not grow normally. The purpose of 
      this study was to determine mandibular length and position in patients with 
      nonsyndromic versus syndromic Robin sequence. PATIENTS AND METHODS: Lateral 
      cephalograms of 51 children with Robin sequence were analyzed. Group I consisted 
      of nonsyndromic (NS) subjects and group II consisted of subjects with the 4 most 
      common syndromic (S) diagnoses. Cephalometric measurements included 
      sella-nasion-A point (SNA), sella-nasion-B point (SNB), sella-nasion-pogonion 
      (SNPg), articulare-gonion-pogonion (ArGoPg), temporomandibular joint-pogonion 
      (TmPg), articulare-gonion (ArGo), and gonion-pogonion (GoPg). Differences between 
      groups and subgroups were compared using t test. RESULTS: There were 26 NS 
      patients (mean age, 6.8 yrs) and 25 S patients (mean age, 8.7 yrs); mean age was 
      statistically different between groups (P = .04); therefore, cephalometric 
      measurements were compared with age-matched normal values. Syndromes included 
      Stickler (n = 10), bilateral facial microsomia (n = 8), velocardiofacial (n = 4), 
      and Treacher Collins (n = 3). SNA was statistically different from normal in both 
      groups (NS, P = .017; S, P = .007); however, SNB was not different from normal 
      for either group (NS, P = .175; S, P = .537). SNPg (0.007) was significantly 
      greater than normal in NS (P = .007) but not in S (P = .702) patients. SNA, SNB, 
      and SNPg were not significantly different between groups. In both groups, 
      mandibular length was short (P = .00), especially in S patients (P = .049), 
      mandibular body was small (NS, P = .00; S, P = .00), and the gonial angle more 
      obtuse (NS, P = .006; S, P = .000) than normal. Ramus length was significantly 
      shorter than normal only in S patients (P = .019). Mandibular length (TmPg) was 
      smaller than normal in all S subgroups but with wide variability. There were 
      statistically significant differences among S subgroups with respect to 
      mandibular sagittal position (SNB, P = .00; SNPg, P = .00) and mandibular length 
      (TmPg, P = .008). There were no differences in S subgroups with respect to age, 
      SNA, ArGo, GoPg, and ArGoPg. CONCLUSION: Mandibular morphology and position are 
      variable in Robin sequence, based on the presence and type of associated 
      syndromic diagnosis.
FAU - Rogers, Gary F
AU  - Rogers GF
AD  - Department of Plastic and Oral Surgery, Children's Hospital Boston, Harvard 
      Medical School, Boston, MA 02115, USA.
FAU - Lim, Asher A T
AU  - Lim AA
FAU - Mulliken, John B
AU  - Mulliken JB
FAU - Padwa, Bonnie L
AU  - Padwa BL
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - J Oral Maxillofac Surg
JT  - Journal of oral and maxillofacial surgery : official journal of the American 
      Association of Oral and Maxillofacial Surgeons
JID - 8206428
SB  - IM
EIN - J Oral Maxillofac Surg. 2009 Dec;67(12):2703. Rogers, Gary [corrected to Rogers, 
      Gary F]
MH  - Adolescent
MH  - Case-Control Studies
MH  - Cephalometry
MH  - Child
MH  - Connective Tissue Diseases/complications/pathology
MH  - Craniofacial Abnormalities/*complications/pathology
MH  - DiGeorge Syndrome/complications/pathology
MH  - Eye Abnormalities/complications/pathology
MH  - Facial Asymmetry/complications/pathology
MH  - *Facies
MH  - Female
MH  - Humans
MH  - Male
MH  - Mandible/abnormalities/*pathology
MH  - Mandibulofacial Dysostosis/complications/pathology
MH  - Matched-Pair Analysis
MH  - Micrognathism/*etiology
MH  - Organ Size
MH  - Pierre Robin Syndrome/*complications/pathology
MH  - Temporomandibular Joint/abnormalities/*pathology
EDAT- 2009/10/20 06:00
MHDA- 2009/11/05 06:00
CRDT- 2009/10/20 06:00
PHST- 2009/03/03 00:00 [received]
PHST- 2009/06/23 00:00 [accepted]
PHST- 2009/10/20 06:00 [entrez]
PHST- 2009/10/20 06:00 [pubmed]
PHST- 2009/11/05 06:00 [medline]
AID - S0278-2391(09)01330-5 [pii]
AID - 10.1016/j.joms.2009.06.010 [doi]
PST - ppublish
SO  - J Oral Maxillofac Surg. 2009 Nov;67(11):2323-31. doi: 10.1016/j.joms.2009.06.010.