PMID- 19837607
OWN - NLM
STAT- MEDLINE
DCOM- 20100706
LR  - 20220310
IS  - 1557-3117 (Electronic)
IS  - 1053-2498 (Print)
IS  - 1053-2498 (Linking)
VI  - 29
IP  - 3
DP  - 2010 Mar
TI  - Quality of life and functional status in patients surviving 12 months after left 
      ventricular assist device implantation.
PG  - 278-85
LID - 10.1016/j.healun.2009.07.017 [doi]
AB  - BACKGROUND: As left ventricular assist device (LVAD) support duration increases, 
      quality of life (QoL) becomes a concern. We reviewed the QoL in patients on LVAD 
      support for >or=1 year. METHODS: We retrospectively reviewed our prospective 
      database for patients supported >or=1 year by HeartMate pulsatile- (HM1) or 
      continuous-flow (HM2) LVADs from 2000 to 2009. Transplant or death before 1 year 
      merited exclusion. Metabolic equivalents of tasks (METs), the Minnesota Living 
      with Heart Failure Questionnaire (MLHFQ), the 6-minute walk distance (6MWD), and 
      New York Heart Association (NYHA) class were reviewed. Complications and 
      re-admissions were assessed. RESULTS: Thirty patients were supported for >or=1 
      year (7 HM1s, 23 HM2s). Mean support duration was 594 +/- 173 days. Mean QoL 
      metrics/functional status indicators at 12 months were: 6MWD, 393 +/- 290 m; MET 
      tolerance, 3.3 +/- 1; MLHFQ, 35 +/- 31; and NYHA, 1.4 +/- 0.6. Mean 
      re-admissions/year was 2.9 +/- 2, with a duration of 13.8 +/- 21 days. Three 
      patients were never re-admitted. Mean out-of-hospital time was 471 +/- 172 days 
      (87.3% of days). Infectious complications led to 43% of re-admissions and 
      occurred in the: drive-line (47%) at 442 +/- 236 days; blood (37%) at 472 +/- 257 
      days; and LVAD pocket (20%) at 550 +/- 202 days. Twenty-three patients (77%) 
      required additional operations (1.7 +/- 1.8/year). The most common indication was 
      drive-line infection, but ranged from ischemic bowel to defibrillator exchange. 
      Eight required LVAD exchanges for mechanical (n = 4), electrical (n = 3), and 
      thrombotic (n = 1) issues. CONCLUSIONS: Although LVAD support is not without 
      complications, patients spend the majority of time outside the hospital enjoying 
      a good quality of life.
FAU - Allen, Jeremiah G
AU  - Allen JG
AD  - Division of Cardiac Surgery, Department of Surgery, The Johns Hopkins University 
      Medical Institutions, Baltimore, Maryland 21287, USA.
FAU - Weiss, Eric S
AU  - Weiss ES
FAU - Schaffer, Justin M
AU  - Schaffer JM
FAU - Patel, Nishant D
AU  - Patel ND
FAU - Ullrich, Susan L
AU  - Ullrich SL
FAU - Russell, Stuart D
AU  - Russell SD
FAU - Shah, Ashish S
AU  - Shah AS
FAU - Conte, John V
AU  - Conte JV
LA  - eng
GR  - T32 DK007713/DK/NIDDK NIH HHS/United States
GR  - T32 DK007713-12/DK/NIDDK NIH HHS/United States
GR  - 2T32DK007713-12/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20091017
PL  - United States
TA  - J Heart Lung Transplant
JT  - The Journal of heart and lung transplantation : the official publication of the 
      International Society for Heart Transplantation
JID - 9102703
SB  - IM
MH  - Adult
MH  - Female
MH  - *Health Status
MH  - Health Surveys
MH  - *Heart-Assist Devices
MH  - Humans
MH  - Male
MH  - Metabolic Equivalent
MH  - Middle Aged
MH  - Prospective Studies
MH  - *Quality of Life
MH  - Retrospective Studies
MH  - Survivors
MH  - Treatment Outcome
MH  - Ventricular Dysfunction, Left/*therapy
MH  - Walking
PMC - PMC2887481
MID - NIHMS187661
EDAT- 2009/10/20 06:00
MHDA- 2010/07/07 06:00
PMCR- 2011/03/01
CRDT- 2009/10/20 06:00
PHST- 2009/06/04 00:00 [received]
PHST- 2009/07/28 00:00 [revised]
PHST- 2009/07/29 00:00 [accepted]
PHST- 2009/10/20 06:00 [entrez]
PHST- 2009/10/20 06:00 [pubmed]
PHST- 2010/07/07 06:00 [medline]
PHST- 2011/03/01 00:00 [pmc-release]
AID - S1053-2498(09)00613-5 [pii]
AID - 10.1016/j.healun.2009.07.017 [doi]
PST - ppublish
SO  - J Heart Lung Transplant. 2010 Mar;29(3):278-85. doi: 
      10.1016/j.healun.2009.07.017. Epub 2009 Oct 17.