PMID- 19839068
OWN - NLM
STAT- MEDLINE
DCOM- 20100113
LR  - 20211020
IS  - 1332-8166 (Electronic)
IS  - 0353-9504 (Print)
IS  - 0353-9504 (Linking)
VI  - 50
IP  - 5
DP  - 2009 Oct
TI  - B-type natriuretic peptide as predictor of heart failure in patients with acute 
      ST elevation myocardial infarction, single-vessel disease, and complete 
      revascularization: follow-up study.
PG  - 449-54
AB  - AIM: To assess the concentration of B-type natriuretic peptide (BNP) as a 
      predictor of heart failure in patients with acute ST elevation myocardial 
      infarction (STEMI) who underwent primary percutaneous coronary intervention (PCI) 
      with successful and complete revascularization. METHODS: Out of a total of 220 
      patients with acute STEMI admitted to the Sisters of Mercy University Hospital in 
      the period January 1 to December 31, 2007, only patients with acute STEMI 
      undergoing primary PCI who had single vessel disease and were successfully 
      revascularized were included in the study. Selected patients had no history of 
      myocardial infarction or heart failure and a normal or near-normal left 
      ventricular ejection fraction (> or =50%) assessed by left ventriculography at 
      admission. Only 58 patients met the inclusion criteria for the study. Out of 
      those, 6 patients refused to participate in the study, and another 5 could not be 
      followed up, so a total of 47 patients were evaluated. Blood samples were taken 
      for measurement of BNP levels at admission, 24 hours later, and 7 days later. 
      Patients were followed up for 1 year. The primary outcome was reduction in left 
      ventricular ejection fraction (LVEF) to <50% after 1 year. RESULTS: Patients who 
      developed echocardiographic signs of reduced systolic function defined as 
      LVEF<50% had significantly higher values of BNP (> or =80 pg/mL) at 24 hours 
      (P=0.001) and 7 days (P=0.020) after STEMI and successful reperfusion. Patients 
      who had BNP levels > or =80 pg/mL after 7 days were 21 times more likely to 
      develop LVEF<50 (odds ratio, 20.8; 95% confidence interval, 2.2-195.2; P=0.008). 
      CONCLUSION: BNP can be used as a predictor of reduced systolic function in 
      patients with STEMI who underwent successful reperfusion and had normal ejection 
      fraction at admission.
FAU - Manola, Sime
AU  - Manola S
AD  - Departmet of Cardiology, Sisters of Mercy University Hospital, Zagreb, Croatia.
FAU - Pavlovic, Nikola
AU  - Pavlovic N
FAU - Radeljic, Vjekoslav
AU  - Radeljic V
FAU - Delic Brkljacic, Diana
AU  - Delic Brkljacic D
FAU - Pintaric, Hrvoje
AU  - Pintaric H
FAU - Stambuk, Kresimir
AU  - Stambuk K
FAU - Bulj, Nikola
AU  - Bulj N
FAU - Trbusic, Matias
AU  - Trbusic M
FAU - Krcmar, Tomislav
AU  - Krcmar T
FAU - Lukinac, Ljerka
AU  - Lukinac L
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - Croatia
TA  - Croat Med J
JT  - Croatian medical journal
JID - 9424324
RN  - 0 (Biomarkers)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - *Angioplasty, Balloon, Coronary
MH  - Biomarkers/blood
MH  - Croatia
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure, Systolic/*blood/diagnosis
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*blood/diagnosis/therapy
MH  - Natriuretic Peptide, Brain/*blood
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - ROC Curve
MH  - Ventricular Dysfunction, Left/blood/diagnosis
PMC - PMC2765742
EDAT- 2009/10/20 06:00
MHDA- 2010/01/14 06:00
PMCR- 2009/10/01
CRDT- 2009/10/20 06:00
PHST- 2009/10/20 06:00 [entrez]
PHST- 2009/10/20 06:00 [pubmed]
PHST- 2010/01/14 06:00 [medline]
PHST- 2009/10/01 00:00 [pmc-release]
AID - CroatMedJ_50_0449 [pii]
AID - 10.3325/cmj.2009.50.449 [doi]
PST - ppublish
SO  - Croat Med J. 2009 Oct;50(5):449-54. doi: 10.3325/cmj.2009.50.449.