PMID- 19841399
OWN - NLM
STAT- MEDLINE
DCOM- 20091110
LR  - 20191210
IS  - 1538-3652 (Electronic)
IS  - 0003-987X (Linking)
VI  - 145
IP  - 10
DP  - 2009 Oct
TI  - Practical guidelines for evaluation of loose anagen hair syndrome.
PG  - 1123-8
LID - 10.1001/archdermatol.2009.220 [doi]
AB  - OBJECTIVES: To better categorize the epidemiologic profile, clinical features, 
      and disease associations of loose anagen hair syndrome (LAHS) compared with other 
      forms of childhood alopecia. DESIGN: Retrospective survey. SETTING: Academic 
      pediatric dermatology practice. Patients Three hundred seventy-four patients with 
      alopecia referred from July 1, 1997, to June 31, 2007. MAIN OUTCOME MEASURES: 
      Epidemiologic data for all forms of alopecia were ascertained, such as sex, age 
      at onset, age at the time of evaluation, and clinical diagnosis. Patients with 
      LAHS were further studied by the recording of family history, disease 
      associations, hair-pull test or biopsy results, hair color, laboratory test 
      result abnormalities, initial treatment, and involvement of eyelashes, eyebrows, 
      and nails. RESULTS: Approximately 10% of all children with alopecia had LAHS. The 
      mean age (95% confidence interval) at onset differed between patients with LAHS 
      (2.8 [1.2-4.3] years) vs patients without LAHS (7.1 [6.6-7.7] years) (P < .001), 
      with 3 years being the most common age at onset for patients with LAHS. All but 1 
      of 37 patients with LAHS were female. The most common symptom reported was thin, 
      sparse hair. Family histories were significant for LAHS (n = 1) and for alopecia 
      areata (n = 3). In 32 of 33 patients, trichograms showed typical loose anagen 
      hairs. Two children had underlying genetic syndromes. No associated laboratory 
      test result abnormalities were noted among patients who underwent testing. 
      CONCLUSIONS: Loose anagen hair syndrome is a common nonscarring alopecia in young 
      girls with a history of sparse or fine hair. Before ordering extensive blood 
      testing in young girls with diffusely thin hair, it is important to perform a 
      hair-pull test, as a trichogram can be instrumental in the confirmation of a 
      diagnosis of LAHS.
FAU - Cantatore-Francis, Julie L
AU  - Cantatore-Francis JL
AD  - Department of Dermatology, New York University School of Medicine, New York 
      University Medical Center, New York, NY 10016, USA.
FAU - Orlow, Seth J
AU  - Orlow SJ
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PL  - United States
TA  - Arch Dermatol
JT  - Archives of dermatology
JID - 0372433
SB  - IM
MH  - Age of Onset
MH  - Alopecia/*diagnosis/*epidemiology/genetics
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Confidence Intervals
MH  - Female
MH  - Follow-Up Studies
MH  - *Guidelines as Topic
MH  - Hair/abnormalities/*ultrastructure
MH  - Humans
MH  - Incidence
MH  - Infant
MH  - Microscopy, Electron
MH  - Probability
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Syndrome
EDAT- 2009/10/21 06:00
MHDA- 2009/11/11 06:00
CRDT- 2009/10/21 06:00
PHST- 2009/10/21 06:00 [entrez]
PHST- 2009/10/21 06:00 [pubmed]
PHST- 2009/11/11 06:00 [medline]
AID - 145/10/1123 [pii]
AID - 10.1001/archdermatol.2009.220 [doi]
PST - ppublish
SO  - Arch Dermatol. 2009 Oct;145(10):1123-8. doi: 10.1001/archdermatol.2009.220.