PMID- 19844107
OWN - NLM
STAT- MEDLINE
DCOM- 20100308
LR  - 20220409
IS  - 1421-9867 (Electronic)
IS  - 0012-2823 (Linking)
VI  - 80
IP  - 4
DP  - 2009
TI  - Management of reflux symptoms with over-the-counter proton pump inhibitors: 
      issues and proposed guidelines.
PG  - 226-34
LID - 10.1159/000235953 [doi]
AB  - BACKGROUND: Symptoms of gastroesophageal reflux are widely prevalent. There is a 
      continuum between subjects with mild reflux symptoms and those severely affected 
      by gastroesophageal reflux disease (GERD). Both groups may at times access 
      over-the-counter (OTC) therapies. For the purpose of this review, relevant 
      papers, including national and international guidelines were reviewed and 
      recommendations made for appropriate use of OTC proton pump inhibitor (PPI) 
      therapy. RESULTS: PPIs are the gold standard for treatment of reflux symptoms. 
      OTC therapy with histamine(2) receptor antagonists (H2RAs) also plays a role. For 
      the majority affected by reflux symptoms, effective symptom control is the most 
      important outcome, as only a subgroup requires investigations or interventions. 
      However, patients with alarm features (i.e. troublesome dysphagia, weight loss, 
      predominant upper abdominal pain) are not recommended for OTC therapy and need 
      prompt medical referral. Frequent relapses or failure to adequately respond to 
      OTC therapy are additional triggers for medical assessment. CONCLUSIONS: OTC 
      treatment of typical reflux symptoms (acid regurgitation, heartburn) with 
      antacids and H2RAs is now accepted as safe and results in short-term relief of 
      symptoms. There is no evidence of additional risk with OTC PPIs compared to these 
      existing OTC therapies and PPIs are significantly more efficacious.
CI  - 2009 S. Karger AG, Basel.
FAU - Haag, Sebastian
AU  - Haag S
AD  - Department of Gastroenterology and Hepatology, University Hospital Essen, Essen, 
      Germany.
FAU - Andrews, Jane M
AU  - Andrews JM
FAU - Katelaris, Peter H
AU  - Katelaris PH
FAU - Gapasin, Judith
AU  - Gapasin J
FAU - Galmiche, Jean Paul
AU  - Galmiche JP
FAU - Hunt, Richard
AU  - Hunt R
FAU - Layer, Peter
AU  - Layer P
FAU - Malfertheiner, Peter
AU  - Malfertheiner P
FAU - Holtmann, Gerald
AU  - Holtmann G
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20091016
PL  - Switzerland
TA  - Digestion
JT  - Digestion
JID - 0150472
RN  - 0 (Nonprescription Drugs)
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Gastroesophageal Reflux/diagnosis/*drug therapy
MH  - Humans
MH  - Nonprescription Drugs/therapeutic use
MH  - Practice Guidelines as Topic
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - Referral and Consultation
RF  - 57
EDAT- 2009/10/22 06:00
MHDA- 2010/03/10 06:00
CRDT- 2009/10/22 06:00
PHST- 2009/10/22 06:00 [entrez]
PHST- 2009/10/22 06:00 [pubmed]
PHST- 2010/03/10 06:00 [medline]
AID - 000235953 [pii]
AID - 10.1159/000235953 [doi]
PST - ppublish
SO  - Digestion. 2009;80(4):226-34. doi: 10.1159/000235953. Epub 2009 Oct 16.