PMID- 19844176
OWN - NLM
STAT- MEDLINE
DCOM- 20100322
LR  - 20161125
IS  - 1473-5733 (Electronic)
IS  - 0957-5235 (Linking)
VI  - 21
IP  - 1
DP  - 2010 Jan
TI  - Low-molecular-weight heparin and unfractionated heparin in prophylaxis against 
      deep vein thrombosis in critically ill patients undergoing major surgery.
PG  - 57-61
LID - 10.1097/MBC.0b013e3283333505 [doi]
AB  - The objective of the present study was to compare the efficacy and safety of 
      low-dose unfractionated heparin (UFH) and a low-molecular-weight heparin (LMWH) 
      as prophylaxis against venous thromboembolism in critically ill surgical patients 
      undergoing major surgery. This was a randomized prospective study in which 
      critically ill patients scheduled to undergo major elective surgery were 
      allocated to receive subcutaneously either LMWH once daily and a placebo 
      injection containing sterile 0.9% normal saline or 5000 IU UFH twice daily 
      subcutaneously. Each patient was evaluated postoperatively clinically and 
      confirmed by Doppler study for development of deep vein thrombosis (DVT). One 
      hundred and fifty-six patients completed the protocol. There was similar efficacy 
      of UFH as compared with LMWH in the prophylaxis of DVT. There was also no 
      statistically significant difference in the incidence of major complications in 
      the heparin group as compared with the LMWH group. However, minor hemorrhagic 
      complications such as wound hematoma and surgical site bleeding were 
      significantly more in the heparin group as compared with the LMWH group. Both UFH 
      5000 units subcutaneously twice daily and LMWH 40 mg once daily provide highly 
      effective and well tolerated prophylaxis for critically ill surgical patients. 
      Considering the advantage of once-daily dosing, a wider adoption of prophylaxis 
      with LMWH may be justified on the basis of patient acceptability and saving of 
      nursing time.
FAU - De, Anushtup
AU  - De A
AD  - General and Minimally Invasive Surgery, Fortis Escorts Hospital and Research 
      Centre, Haryana, India. anustupdey@hotmail.com
FAU - Roy, Prabal
AU  - Roy P
FAU - Garg, Vinod K
AU  - Garg VK
FAU - Pandey, Narendra K
AU  - Pandey NK
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - England
TA  - Blood Coagul Fibrinolysis
JT  - Blood coagulation & fibrinolysis : an international journal in haemostasis and 
      thrombosis
JID - 9102551
RN  - 0 (Anticoagulants)
RN  - 0 (Enoxaparin)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anticoagulants/administration & dosage/adverse effects/*therapeutic use
MH  - *Critical Illness
MH  - Drug Administration Schedule
MH  - *Elective Surgical Procedures
MH  - Enoxaparin/administration & dosage/adverse effects/*therapeutic use
MH  - Female
MH  - Follow-Up Studies
MH  - Hemorrhage/chemically induced/epidemiology
MH  - Heparin/administration & dosage/adverse effects/*therapeutic use
MH  - Humans
MH  - Injections, Subcutaneous
MH  - Male
MH  - Middle Aged
MH  - Postoperative Complications/chemically induced/diagnostic 
      imaging/epidemiology/*prevention & control
MH  - *Premedication
MH  - Prospective Studies
MH  - Risk Factors
MH  - Ultrasonography
MH  - Venous Thrombosis/diagnostic imaging/*prevention & control
EDAT- 2009/10/22 06:00
MHDA- 2010/03/23 06:00
CRDT- 2009/10/22 06:00
PHST- 2009/10/22 06:00 [entrez]
PHST- 2009/10/22 06:00 [pubmed]
PHST- 2010/03/23 06:00 [medline]
AID - 10.1097/MBC.0b013e3283333505 [doi]
PST - ppublish
SO  - Blood Coagul Fibrinolysis. 2010 Jan;21(1):57-61. doi: 
      10.1097/MBC.0b013e3283333505.