PMID- 1984480
OWN - NLM
STAT- MEDLINE
DCOM- 19910125
LR  - 20190510
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 163
IP  - 1
DP  - 1991 Jan
TI  - Divergent efficacy of antibody to tumor necrosis factor-alpha in intravascular 
      and peritonitis models of sepsis.
PG  - 83-8
AB  - The role of tumor necrosis factor-alpha (TNF alpha) in the lethal consequences of 
      intravascular lipopolysaccharide (LPS) or Escherichia coli sepsis was compared 
      with that in bacterial peritonitis. Intravenous administration of E. coli LPS or 
      E. coli (live or dead) resulted in large transient increases in serum TNF alpha 
      levels, peaking at 90 min at 10,000-30,000 units/ml. In contrast, the serum TNF 
      alpha response following the induction of bacterial peritonitis was substantially 
      less, peaking at 200-500 units/ml. Sterile peritonitis (essentially nonlethal) 
      and bacterial peritonitis (greater than 60% lethal) elevated TNF alpha levels to 
      1000-2000 units/lavage within the peritoneal cavity 2 h after challenge. Passive 
      immunization with neutralizing goat anti-TNF alpha IgG improved survival from 8% 
      to 75% in rats administered LPS intravenously but was completely ineffective in 
      protecting rats from lethal E. coli peritonitis. Thus significant differences 
      exist in the role TNF alpha plays in systemic intravascular models of sepsis and 
      bacterial peritonitis.
FAU - Bagby, G J
AU  - Bagby GJ
AD  - Department of Physiology, Louisiana State University Medical Center, New Orleans 
      70112.
FAU - Plessala, K J
AU  - Plessala KJ
FAU - Wilson, L A
AU  - Wilson LA
FAU - Thompson, J J
AU  - Thompson JJ
FAU - Nelson, S
AU  - Nelson S
LA  - eng
GR  - AA-07710/AA/NIAAA NIH HHS/United States
GR  - GM-32654/GM/NIGMS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Lactates)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - Disease Models, Animal
MH  - Escherichia coli
MH  - Escherichia coli Infections/etiology/*therapy
MH  - *Immunization, Passive
MH  - Lactates/blood
MH  - Lipopolysaccharides
MH  - Male
MH  - Peritonitis/etiology/*therapy
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Sepsis/etiology/*therapy
MH  - Tumor Necrosis Factor-alpha/biosynthesis/*immunology
EDAT- 1991/01/01 00:00
MHDA- 1991/01/01 00:01
CRDT- 1991/01/01 00:00
PHST- 1991/01/01 00:00 [pubmed]
PHST- 1991/01/01 00:01 [medline]
PHST- 1991/01/01 00:00 [entrez]
AID - 10.1093/infdis/163.1.83 [doi]
PST - ppublish
SO  - J Infect Dis. 1991 Jan;163(1):83-8. doi: 10.1093/infdis/163.1.83.