PMID- 1984481
OWN - NLM
STAT- MEDLINE
DCOM- 19910125
LR  - 20190510
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 163
IP  - 1
DP  - 1991 Jan
TI  - Pretreatment with ibuprofen augments circulating tumor necrosis factor-alpha, 
      interleukin-6, and elastase during acute endotoxinemia.
PG  - 89-95
AB  - Plasma levels of tumor necrosis factor-alpha (TNF alpha), interleukin-1 (IL-1), 
      and interleukin-6 (IL-6) were monitored after intravenous administration of 
      Escherichia coli endotoxin with or without ibuprofen pretreatment to healthy 
      volunteers. Intravenous endotoxin (n = 7) resulted in elevated plasma TNF alpha 
      concentrations with maximal levels at 90 min (369 +/- 44 pg/ml, P less than .001 
      vs. saline controls, n = 7). The rise in TNF-alpha was followed by a rise in 
      plasma IL-6 (27 +/- 12.8 ng/ml), peaking 30-90 min thereafter. Pretreatment with 
      ibuprofen (n = 6) caused a significant augmentation and temporal shift in 
      cytokine elaboration with maximal TNF alpha levels (627 +/- 136 pg/ml) at 120 min 
      and IL-6 peaks (113 +/- 66 ng/ml) at 180 min. In ibuprofen-treated volunteers, 
      the additional increase in TNF alpha was paralleled by increased levels of 
      circulating elastase. In vitro experiments suggest a causal relationship between 
      these events. Thus, the cyclooxygenase inhibitor ibuprofen blunts the clinical 
      response to endotoxin but augments circulating cytokine levels and leukocyte 
      degranulation.
FAU - Spinas, G A
AU  - Spinas GA
AD  - Department of Internal Medicine, University Hospital, Basel, Switzerland.
FAU - Bloesch, D
AU  - Bloesch D
FAU - Keller, U
AU  - Keller U
FAU - Zimmerli, W
AU  - Zimmerli W
FAU - Cammisuli, S
AU  - Cammisuli S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Endotoxins)
RN  - 0 (Interleukin-1)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - EC 3.4.21.36 (Pancreatic Elastase)
RN  - WK2XYI10QM (Ibuprofen)
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Blood Pressure
MH  - Body Temperature
MH  - Cell Degranulation
MH  - Endotoxins/*blood
MH  - Escherichia coli
MH  - Heart Rate
MH  - Humans
MH  - Ibuprofen/*therapeutic use
MH  - Interleukin-1/blood
MH  - Interleukin-6/*blood
MH  - Least-Squares Analysis
MH  - Leukocyte Count
MH  - Male
MH  - Neutrophils/enzymology/physiology
MH  - Pancreatic Elastase/*blood
MH  - Regression Analysis
MH  - Tumor Necrosis Factor-alpha/*analysis
EDAT- 1991/01/01 00:00
MHDA- 1991/01/01 00:01
CRDT- 1991/01/01 00:00
PHST- 1991/01/01 00:00 [pubmed]
PHST- 1991/01/01 00:01 [medline]
PHST- 1991/01/01 00:00 [entrez]
AID - 10.1093/infdis/163.1.89 [doi]
PST - ppublish
SO  - J Infect Dis. 1991 Jan;163(1):89-95. doi: 10.1093/infdis/163.1.89.